Total synthesis and structure-activity relationship study of pyripyropene A, a potent and selective ACAT2 Inhibitor
| Project/Area Number |
22590011
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 合成化学 / 創薬化学 / pyripyropene A / ACAT2 / ACAT2阻害剤 / 全合成 / 構造活性相関研究 / 創薬研究 / 新規抗高脂血症薬 / Pyripyropene A / 構造活性相関 / 創薬 |
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| Research Abstract |
We have achieved a stereocontrolled total synthesis of pyripyropene A (1), a potent ACAT2 inhibitor with high isozyme selectivity. Extension of this chemistry for the structure-activity relationship study successfully produced new A-ring truncated pyripyropene A analogs.
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Report
(4 results)
Research Products
(41 results)
