Catalytic Enantioselective Synthesis of None-amide Type N-C Axially Chiral Compounds and Their Application to Asymmetric Reaction
| Project/Area Number |
22590015
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Shibaura Institute of Technology |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 軸不斉 / アトロプ異性 / 光学活性 / パラジウム / アミノ化 / インドール / キノリノン / 不斉触媒 / 不斉ホスフィン / アミノ環化 |
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| Research Abstract |
We succeeded in the catalytic enantioselective synthesis of N-C axially chiral indole and 4-quinolinone derivatives through chiral palladium-catalyzed amination, and the determination of their absolute configurations. Furthermore, notable relationship between the structure and the rotational barrier was found．
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Report
(4 results)
Research Products
(34 results)
