Enantioselective synthesis of axially chiral biaryl compoundscomposed of condensed polyaromatic units
Project/Area Number |
22590018
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Chemical pharmacy
|
Research Institution | Tokyo University of Pharmacy and Life Science |
Principal Investigator |
|
Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | 有機化学 / ビアリール / 軸不斉 / 天然物合成 / 合成化学 / 生理活性 / 酵素 |
Research Abstract |
The project was carried out with the aim of exploring the synthetic methodology for the axially chiral natural products, which are composed of plural units of condensed polyaromatic derivatives. Development of the reliable methods for enantioselective synthesis of multiply functionalized biphenyl compounds, and the methods for effective annulation on the biphenyl framework culminated in the first total syntheses of two natural products, euxanmodin B and dermocanarin II.
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Report
(4 results)
Research Products
(20 results)