Synthetic Studies on Structurally Novel Antitumor Natural Products, Hederacines

• Project/Area Number: 22590020
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Chemical pharmacy
• Research Institution: Tokyo University of Pharmacy and Life Science
• Principal Investigator: AOYAGI Sakae 東京薬科大学, 薬学部, 教授 (30212385)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 合成化学 / 天然物合成化学 / 天然物合成

Research Abstract

Hederacines A and B, isolated from Glechoma hederaceae, have structurescontaining anuniqueaza-tricycles and show moderate levels of cytotoxicity. In this study, racemic syntheses of 9-epi-hederacine A and 9-epi-hederacine B were achieved via a potential common intermediateprecursor.

Research Products

• [Journal Article] Toward the Racemic Total Synthesis of Hederacines A and B : Construction of an Advanced Tricyclic Intermediate (2011)
  • Author(s): Miho Yamashita, Tetsuya Yamashita, Sakae Aoyagi
  • Journal Title: Organic Letters Volume: 13 Pages: 2204-2207
  • Peer Reviewed