Studies on the synthesis of potent antitumor hybrids of the spliceosome inhibitors FR901464 and pladienolide
| Project/Area Number |
22590022
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Hoshi University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 合成化学 / スプライシング阻害剤 / FR901464 / pladienolide / ハイブリッド誘導体 / SF3b / Dladienolide |
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| Research Abstract |
Since FR901464 and pladienolide have a very similar mechanism that would be the inhibition of SF3b, we developed a hypothetical hybrid that could have similar biological activity. We have succeeded in the synthesis of each parts of FR901464 and pladienolide.
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Report
(4 results)
Research Products
(11 results)
