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Studies on the synthesis of potent antitumor hybrids of the spliceosome inhibitors FR901464 and pladienolide

Research Project

Project/Area Number 22590022
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Chemical pharmacy
Research InstitutionHoshi University

Principal Investigator

TSUBUKI Masayoshi  星薬科大学, 薬学部, 教授 (90163865)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords合成化学 / スプライシング阻害剤 / FR901464 / pladienolide / ハイブリッド誘導体 / SF3b / Dladienolide
Research Abstract

Since FR901464 and pladienolide have a very similar mechanism that would be the inhibition of SF3b, we developed a hypothetical hybrid that could have similar biological activity. We have succeeded in the synthesis of each parts of FR901464 and pladienolide.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (11 results)

All 2012 2011 2010 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (3 results) Remarks (2 results)

  • [Journal Article] Synthesis and Evaluation of 4-Aryl-2(1H)-quinolinones as Potent Amyloid ss Fibrillogenesis Inhibitors2012

    • Author(s)
      Y. Shimokawa, M. Nakakoshi, S. Saitoh, H. Suzuki, Y. Yokoyama, A. Ishigami, H. Nishioka, and M. Tsubuki
    • Journal Title

      Heterocycles

      Volume: Vol. 85 Pages: 1933-1940

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis and Evaluation of 4-Aryl-2(1H)-quinolinones as Potent Amyloid β Fibrillogenesis Inhibitors2012

    • Author(s)
      Yoko Shimokawa
    • Journal Title

      Heterocycles

      Volume: 85 Issue: 8 Pages: 1933-1940

    • DOI

      10.3987/com-12-12506

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] New Type of Matrix for Analysis of Low Molecular Weight Compounds by MALDI-TOF MS2012

    • Author(s)
      中越雅道
    • Journal Title

      Heterocycles

      Volume: 85 Issue: 4 Pages: 927-932

    • DOI

      10.3987/com-12-12438

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] タンパク質翻訳阻害作用機構に基づく新規ながん治療薬の創製2011

    • Author(s)
      津吹政可
    • Journal Title

      星薬科大学紀要

      Volume: Vol.53 Pages: 1-7

    • NAID

      40019183964

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Proteomic Analysis of Two Types of Exosomes in Human Whole Saliva2011

    • Author(s)
      小川裕子
    • Journal Title

      Biol.Pharm.Bull.

      Volume: 34 Pages: 13-23

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enantioselective Synthesis of the C(2)-C(11) Cyclopropylfuran Segment of Pinnatin J2010

    • Author(s)
      M. Tsubuki, T. Abekura, K. Takahashi, and T. Honda
    • Journal Title

      Heterocycles

      Volume: Vol.82 Pages: 319-323

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Presentation] スプライシング因子阻害活性を有するプラジエノリド及び FR901464 の合成研究 Part 12012

    • Author(s)
      横江弘雅、 武井友香里、 松村茉莉、津吹政可
    • Organizer
      オープン・リサーチ・センター整備事業研究報告会
    • Place of Presentation
      星薬科大学
    • Year and Date
      2012-02-23
    • Related Report
      2012 Final Research Report
  • [Presentation] スプライシング因子阻害活性を有するプラジエノリド及びFR901464の合成研究Part22012

    • Author(s)
      岡野恵里、齊藤友加里、津吹政可
    • Organizer
      オープン・リサーチ・センター整備事業研究報告会
    • Place of Presentation
      星薬科大学
    • Year and Date
      2012-02-23
    • Related Report
      2012 Final Research Report
  • [Presentation] スプライシング因子阻害作用を有するプラジエノリド及びFR901464の合成研究2011

    • Author(s)
      岡野恵里、齊藤友加里、武井友香里、松村茉莉、津吹政可
    • Organizer
      第55回日本薬学会関東支部大会
    • Place of Presentation
      千葉
    • Year and Date
      2011-10-08
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Remarks]

    • URL

      http://polaris.hoshi.ac.jp/kyoshitsu/seitaiyuki/index.html

    • Related Report
      2012 Final Research Report
  • [Remarks] 星薬科大学生体分子有機学研究室ホームページ

    • URL

      http://polaris.hoshi.ac.jp/kyoshitsu/seitaiyuki/index.html

    • Related Report
      2012 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

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