Bioorganic Studies on Neurotrophic Natural Products
| Project/Area Number |
22590029
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Tokushima Bunri University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 神経栄養因子活性 / 神経変性疾患 / 神経新生、ネオビブサニン、タアラアミデイン / フェニルブタノイドダイマー / 神経細胞培養 / 神経栄養因子 / ネオビブサニン / タアラアミデイン / フェニルブテノイドダイマー / 神経再生 / OBXマウス / PC12細胞 / 神経新生 / 嗅球摘出マウス / パラジウム触媒反応 / 天然物 / 細胞内シグナル伝達 / 全合成 / 分子プローブ |
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| Research Abstract |
We have carried out bioorganic chemical studies on four neurotrophic natural products which we found. As results, formal asymmetric synthesis of neovibsanin has been completed, and also its minimum structure unit has been clarified. All seven stereoisomers of talaumdin have been synthesized, resulting in proposing the most active isomer in which all four substituents are deposited down on THP. Moreover, neovibsanin, talaumidin, and penylbutane dimer have been found to enhance neurogenesis in mouse hippocampus. In addition, both the fluorescent and photoaffinity labeling probes of neovibsanin active derivative have been successfully prepared.
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Report
(4 results)
Research Products
(97 results)
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[Journal Article] Syntheses of Structurally-simplified and Fluorescently-labeled Neovibsanin Derivatives and Analysis of their Neurite Outgrowth Activity in PC12 Cells.2012
Author(s)
H.Imagawa, H. Siajo, H. Yamaguchi, K. Maekwa, T. Kurisaki, H. Yamamoto, M. Nishizawa, M. Oda, M. Kaubura, M. Nagahama, J. Sakurai, M. Nakai, K. Makino, M. Ogata, H. Takahashi, Y. Fukuyama
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Journal Title
Bioorg. Med. Chem. Lett.
Volume: 22,(5)
Issue: 5
Pages: 2089-2093
DOI
Related Report
Peer Reviewed
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