| Project/Area Number |
22590032
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Tokushima Bunri University |
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Principal Investigator |
TSUNODA Tetsuto 徳島文理大学, 大学院・薬学研究科, 教授 (00172049)
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| Co-Investigator(Kenkyū-buntansha) |
HORIKAWA Mitsuyo 徳島文理大学, 大学院・薬学研究科, 助教 (50148772)
KAKU Hiroto 徳島文理大学, 大学院・薬学研究科, 講師 (90299339)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
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| Keywords | 新光延試薬 / 不斉分子認識 / デラセミ化 / 不斉全合成 / アンチマイシン / アブラムシ色素 / 分子認識 / スルホニル基 / 不斉前合成 |
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| Research Abstract |
We developed efficient method to convert molecular structure utilizing newMitsunobu reaction and kinetic molecular recognition. For example, the use of host molecule withalkaline converted racemic 3-benzy-2-hexanone and to the S-isomer of 99% ee in 93% yield.Furthermore, new Mitsunobu reagents such as CMBP and CMMP prepared were mediated C-C and C-Nforming reaction in excellent yield. Utilizing these new reaction, we synthesized biologically activenatural products.
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