| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Research Abstract |
The nucleic acid molecule responds to the existing environment like the metal concentration and forms the various structures. The iron storage protein adopts the shell structure like to liposome and becomes a novel drug carrier to deliver nucleic acid and to release it at the target cell. The new crystal lattice structure of the candidate protein has been determined in six forms, in which the metal ions such as ferric, zinc and cadmium ions are doped. The highly solvated packing of the dodecamer shell is suitable for the crystallographic study of the metal ion uptake pathway.
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