Basic research for development of novel switch part on conformation and delivery of nucleic acid
| Project/Area Number |
22590039
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Physical pharmacy
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| Research Institution | University of Shizuoka |
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Principal Investigator |
FUJII Satoshi 静岡県立大学, 薬学部, 客員教授 (10107104)
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| Co-Investigator(Kenkyū-buntansha) |
YOKOYAMA Hideshi 静岡県立大学, 薬学部, 講師 (70433208)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 生物物理化学 / X線結晶解析 / 薬物送達 / 金属配位様式 |
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| Research Abstract |
The nucleic acid molecule responds to the existing environment like the metal concentration and forms the various structures. The iron storage protein adopts the shell structure like to liposome and becomes a novel drug carrier to deliver nucleic acid and to release it at the target cell. The new crystal lattice structure of the candidate protein has been determined in six forms, in which the metal ions such as ferric, zinc and cadmium ions are doped. The highly solvated packing of the dodecamer shell is suitable for the crystallographic study of the metal ion uptake pathway.
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] Novel candesartan derivatives as indoleamine 2, 3-dioxygenase inhibitors2012
Author(s)
Matsuno K, Yamazaki H, Isaka Y, takai K, Unno Y, Ogo N, Ishikawa Y, Fujii S, Takikawa O, Asai A
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Journal Title
Med. Chem. Comm.
Volume: 3
Issue: 4
Pages: 475-479
DOI
Related Report
Peer Reviewed
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[Journal Article] ortho-Selective Nucleophilic ddition of Primary Amines to Silylbenzynes: Synthesis of 2-Silylanilines2011
Author(s)
T. Ikawa, T. Nishiyama, T. Shigeta, S. Mohri, S. Morita, S. Takayanagi, Y. Terauchi, Y. Morikawa, A. Takagi, Y. Ishikawa, S. Fujii, Y. Kita, S. Akai
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Journal Title
Angew. Chem. Int. Ed.
Volume: 50巻
Pages: 5674-5677
Related Report
Peer Reviewed
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[Journal Article] ortho-Selective Nucleophilic Addition of Primary Amines to Silylbenzynes : Synthes is of 2-Silylanilines2011
Author(s)
T.Ikawa, T.Nishiyama, T.Shigeta, S.Mohri, S.Morita, S.Takayanagi, Y.Terauchi, Y.Morikawa, A.Takagi, Y.Ishikawa, S.Fujii, Y.Kita, S.Akai
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Journal Title
Angew.Chem.Int.Ed.
Volume: 50
Pages: 5674-5677
Related Report
Peer Reviewed
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