| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
As to nanoparticles design for treatment of glioma, seven-folates modified-β-cyclodextrin-anticancer drug were synthesized for specific targeting of drug to cancer cells. OCT3131, which is new candidate for anti-tuberculosis drug and highly water-soluble, was covered with hydrophobic surfactant to be nanoparticles. The nanoparticles can be existed as particles even in deeper site of lungs. Inhalable microparticles including OCT313 nanoparticles were prepared and it was successful to deliver drug in high efficient to alveolar macrophages which tuberculosis hides.
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