| Project/Area Number |
22590044
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Physical pharmacy
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| Research Institution | Aichi Gakuin University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
FUKUDA Mitsuo 愛知学院大学, 歯学部, 教授 (40156790)
OGAWA Noriko 愛知学院大学, 薬学部, 助教 (80409359)
田原 耕平 愛知学院大学, 薬学部, 助教 (30454325)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | バイオフィルム感染症 / 生分解性高分子ナノ粒子 / 表面修飾 / ドラッグデリバリーシステ ム / 歯周病 / キトサン / ナノ粒子 / 抗菌剤 / ドラッグデリバリーシステム / 生分解性高分子 |
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| Research Abstract |
Biofilms increased resistance to detergents and antibiotics, as the dense extracellular matrix and the outer layer of cells protect the interior of the community. These biofilms cause the intractable infections. Therefore, the development of antibacterial drug delivery systems for treatment of biofilm infection disease is strongly desired. We intended to design surface modified PLGA nanoparticle for antibacterial drug delivery to the bacteria in the biofilm. CS-modified PLGA NP indicated the strongly antibacterial effect and suppression of biofilm formation. Because CS-modified NP could adsorb on the negatively charged biofilms and deliver antibacterial drug to biofilm formed with bacteria, in which the high concentration gradient of CAM was formed. Therefore, CS-modified PLGA NP has a high potential to be used in biofilm infection disease therapy.
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