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Protection of Humidity of Drugs by Using a Hydrotalcite as a Molecular Capsule

Research Project

Project/Area Number 22590047
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Physical pharmacy
Research InstitutionKobe Pharmaceutical University

Principal Investigator

HIROKAZU Nakayama  神戸薬科大学, 薬学部, 教授 (40189080)

Co-Investigator(Kenkyū-buntansha) HAYASHI Aki  神戸薬科大学, 薬学部, 助教 (80309434)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Keywordsハイドロタルサイト / 吸湿性 / インターカレーション
Research Abstract

We can successfully attain the improvement of hygroscopicity of various drugs,thatis, sodium valproate, diclofenac sodium, betamethasone sodium phosphate,pravastatin sodium and levofolinate calcium, by synthesizing intercalationcompounds.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (15 results)

All 2012 2011 2010 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (9 results) Book (2 results)

  • [Journal Article] Phosphonylation of Catechin with Sodium Diphosphonate in Aqueous Solu-tion2012

    • Author(s)
      H. Maeda
    • Journal Title

      Phosphorus Res. Bull.

      Volume: 27 Pages: 6-10

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ハイドロタルサイトへのインターカレーションに伴う特異な挙動とその応用の可能性2011

    • Author(s)
      中山尋量
    • Journal Title

      粘土科学

      Volume: 50巻、3号 Pages: 93-98

    • NAID

      130006964784

    • URL

      http://www.cssj2.org/nendokagaku/back_number/vol50_no3.html

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tsuhako, Encapsulation of Nucleotides and DNA into Mg-Al Layered Double Hydroxide2010

    • Author(s)
      H. Nakayama, A, Hatakeyama, and M.
    • Journal Title

      Int. J. Pharm

      Volume: Vol.393,No.1-2 Issue: 1-2 Pages: 105-112

    • DOI

      10.1016/j.ijpharm.2010.04.013

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Encapulation of Nucleotides and DNA into Mg-Al Layered Double Hydroxide2010

    • Author(s)
      Hirokazu Nakayama, et., al.
    • Journal Title

      Int.J.Pharm.

      Volume: 39 Pages: 105-112

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 層状複水酸化物との複合体による医薬品の吸湿性評価2012

    • Author(s)
      中山尋量, 他
    • Organizer
      第132回日本薬学会年会
    • Place of Presentation
      札幌
    • Year and Date
      2012-03-31
    • Related Report
      2011 Annual Research Report
  • [Presentation] シクロデキストリンによるメラトニンの包接能評価2012

    • Author(s)
      前田秀子、小川優、中山尋量
    • Organizer
      日本化学会第93春季年会
    • Place of Presentation
      草津
    • Year and Date
      2012-03-24
    • Related Report
      2012 Final Research Report
  • [Presentation]2011

    • Author(s)
      H. Nakayama, and A. Hayashi
    • Organizer
      International Symposium of Intercalation Chemistry (ISIC16)
    • Place of Presentation
      Sec-Ustupky (Czech Republic)
    • Year and Date
      2011-05-24
    • Related Report
      2012 Final Research Report
  • [Presentation] Solid-solid Intercalation Reaction of Layered Double Hydroxide2011

    • Author(s)
      Hirokazu Nakayama
    • Organizer
      International Symposium of Intercalation Chemistry
    • Place of Presentation
      Sec-Ustupky, Czech Republic
    • Year and Date
      2011-05-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] 層状複水酸化物との複合体による医薬品の吸湿性評価2011

    • Author(s)
      久保田舞、岡村美希、吉田啓祐、林亜紀、中山尋量
    • Organizer
      第132回日本薬学会年会
    • Place of Presentation
      札幌
    • Year and Date
      2011-03-31
    • Related Report
      2012 Final Research Report
  • [Presentation] ハイドロタルサイトへのインターカレーションに伴う特異な挙動とその応用の可能性2010

    • Author(s)
      中山尋量
    • Organizer
      第54回粘土科学討論会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-09-07
    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Presentation] 層状複水酸化物を用いた一リン酸の回収と放出

    • Author(s)
      中山尋量、林 亜紀、他
    • Organizer
      第22回無機リン化学討論会
    • Place of Presentation
      神戸
    • Related Report
      2012 Annual Research Report
  • [Presentation] 無機環状三リン酸塩による分岐鎖アミノ酸のリン酸化反応

    • Author(s)
      中山尋量、他
    • Organizer
      第22回無機リン化学討論会
    • Place of Presentation
      神戸
    • Related Report
      2012 Annual Research Report
  • [Presentation] シクロデキストリンによるメラトニンの包接能評価

    • Author(s)
      中山尋量、他
    • Organizer
      日本化学会第93春季年会
    • Place of Presentation
      草津
    • Related Report
      2012 Annual Research Report
  • [Book] 機能性粘土素材の最新動向2010

    • Author(s)
      中山尋量、他
    • Publisher
      シーエムシー出版
    • Related Report
      2012 Final Research Report
  • [Book] 機能性粘土素材の最新動向2010

    • Author(s)
      中山尋量, 他(共著;分担)
    • Total Pages
      7
    • Publisher
      シーエムシー出版
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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