| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Research Abstract |
MDGA1 encodes a GPI-anchored IgSF molecule containing MAM domain, which we isolated as a gene expressed by a specific subset of spinal and DRG neurons. In mouse cerebral cortex, MDGA1 is selectively expressed by neurons located in the upper layer. To investigate the function of MDGA1 and MDGA2, the other family member of MDGA1, in corticogenesis, we generated the MDGA1 and MDGA2 deficient mice. The migration of MDGA1/2-mutant neurons to the superficial cortical plate was clearly delayed, indicating that MDGA family proteins are involved in radial migration of projection neurons. The results also indicated that MDGA1 was expressed by and required for a subset of upper layer neurons for their proper migration. Theses observations suggested that radial migration of upper layer neurons in the cortical plate might be differentially regulated among cell types.
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