| Project/Area Number |
22590056
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
|
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| Research Institution | Kyoto Pharmaceutical University (2012)
Chiba University (2010-2011) |
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Principal Investigator |
NAKAYAMA Yuji 京都薬科大学, 薬学部, 教授 (10280918)
|
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| Co-Investigator(Kenkyū-buntansha) |
FUKUMOTO Yasunori 千葉大学, 大学院・薬学研究院, 助教 (10447310)
YAMAGUCHI Naoto 千葉大学, 大学院・薬学研究院, 教授 (00166620)
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| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 細胞分裂 / チロシンリン酸化 / Src チロシンキナーゼ / Src型チロシンキナーゼ / 癌 / 分裂期スピンドル |
|---|
| Research Abstract |
Cell division is tightly regulated in order to prevent cancers, cancer progression and cell death. In this study, we showed that tyrosine phosphorylation signaling by Src-family tyrosine kinases is important for regulation of mitotic spindle formation. In addition, cytokinesis fails upon an increase in Src activity, resulting in generation of binucleated cells.
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