Research Project
Grant-in-Aid for Scientific Research (C)
We have found that cholesterol is accumulated in a brain and renal functions reduce in mice fed a high cholesterol diet. In this research, it was aimed to clarify the mechanism of increase of the vascular permeability by hypercholesterolemia of mice fed a high cholesterol diet. In the high cholesterol fed-mice, the activity of MMP9 in blood increased intentionally. The ratio of the lymphocyte in blood decreased, and that of neutrophils statistically increased. These data suggested that the permeability of BBB might be increased by MMP9 derived from neutrophils which degrades ZO-1.When mice fed a high cholesterol diet were treated ezetimibe or cholestyramine, the blood cholesterol level, MMP9 level and the ratio of the neutrophil in blood decreased. Especially, the cholestyramine which induces bile acid excretion also recovered HDL level, inhibition of induction of BBB permeability was high, and a part of renal function was also recovered. Since we found that acrolein increased in blood of hypercholesterolemia of mice fed a high cholesterol diet, we clarify whether lipoproteins modified with acrolien induces to form foam cells from macrophages.
All 2013 2012 2011 Other
All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (8 results) (of which Invited: 2 results) Remarks (1 results)
Atherosclerosis
Volume: 227(1) Pages: 51-7
Clin. Chim.Acta
Volume: 413(7-8) Pages: 753-9
Clin. Chim. Acta
Volume: 413(7-8) Issue: 7-8 Pages: 753-9
10.1016/j.cca.2012.01.020
Mol. Pharm
Volume: 8 Pages: 1962-9
Biochim. Biophys. Acta -Gen. Subjects
Volume: 1810 Pages: 1309-16
Mol.Pharm.
Biochim.Biophys.Acta-Gen.Subjects
http://www.p.chiba-u.ac.jp/lab/byouyaku/index.html
