| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
This proposal investigated roles of prostaglandin E (PGE) on the growth, angiogenesis, and bone lose associated with bone metastasis of cancer. In the mouse models of tumor growth and bone metastasis, PGE produced by host cells is essential and EP4 antagonist suppresses the growth and metastasis of cancer in vitro and in vivo.
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