Roles of prostaglandin E on the growth and bone metastasis of cancer.
| Project/Area Number |
22590058
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Biological pharmacy
|
|---|
| Research Institution | Tokyo University of Agriculture and Technology |
|---|
Principal Investigator |
MIYAURA Chisato 東京農工大学, 大学院・工学研究院, 教授 (20138382)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
INADA Masaki 東京農工大学, 大学院・工学研究院, 准教授 (80401454)
HIRATA Michiko 東京農工大学, 大学院・工学研究院, 講師 (40544060)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | プロスタグランジンE / がんの骨転移 / 固形腫瘍 / がん |
|---|
| Research Abstract |
This proposal investigated roles of prostaglandin E (PGE) on the growth, angiogenesis, and bone lose associated with bone metastasis of cancer. In the mouse models of tumor growth and bone metastasis, PGE produced by host cells is essential and EP4 antagonist suppresses the growth and metastasis of cancer in vitro and in vivo.
|
Report
(4 results)
Research Products
(83 results)
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] J.Pharmacol.Sci.2011
Author(s)
Harada S
-
Journal Title
Nobiletin, a polymethoxy flavonoid, suppresses bone resorption by inhibiting NF κ B-dependent prostaglandin E synthesis in osteoblasts, and prevents bone loss due to estrogen deficiency.
Volume: 115
Pages: 89-93
Related Report
Peer Reviewed
-
-
-
[Journal Article] J.Health Sci.2010
Author(s)
Hirata M
-
Journal Title
Cell Shape and Matrix Production of Fibroblasts cultured on fibroi n-organized scaffold with type-II-turn structured (Ala-Gly-Ala-Gly-Ser-Gly)_n sequences.
Volume: 56
Pages: 1-7
Related Report
Peer Reviewed
-
[Journal Article] Prion2010
Author(s)
Kim J
-
Journal Title
Pyrroloquinoline quinone inhibits the fibrillation of amyloid proteins.
Volume: 4
Pages: 26-31
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
