| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
Calcitonin gene-related peptide (CGRP) suppressed Th1 differentiation and induced Th2, Th9, and Th17 differentiation via activation of the cAMP/protein kinase A pathway and inactivation of GSK-3β leading to nuclear localization of NFATc2. In CGRP receptor-deficient mice, airway inflammation and experimental autoimmune encephalomyelitis were suppressed. Moreover, we found that airway and skin inflammation were promoted by increased production and release of CGRP from mice exposed by chemicals in neonatal.
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