Investigation of host defense mechanisms by sensory nerve transmitter CGRP
| Project/Area Number |
22590062
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | CGRP / Th 細胞 / 神経系 / 環境因子 / 化学物質 / Th細胞 / 感覚神経 / 食物アレルギー / 接触過敏症 / 多発性硬化症 / CGRP受容体欠損マウス / 生体防御系 / カルシトニン遺伝子関連ペプチド / 接触性過敏症 |
|---|
| Research Abstract |
Calcitonin gene-related peptide (CGRP) suppressed Th1 differentiation and induced Th2, Th9, and Th17 differentiation via activation of the cAMP/protein kinase A pathway and inactivation of GSK-3β leading to nuclear localization of NFATc2. In CGRP receptor-deficient mice, airway inflammation and experimental autoimmune encephalomyelitis were suppressed. Moreover, we found that airway and skin inflammation were promoted by increased production and release of CGRP from mice exposed by chemicals in neonatal.
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Report
(4 results)
Research Products
(43 results)
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[Journal Article] Neuropeptide deficient mice have attenuated nociceptive, vascular, and inflammatory changes in a tibia fracture model of complex regional pain syndrome2012
Author(s)
Guo TZ, Wei T, Shi X, Li WW, Hou S, Wang L, Tsujikawa K, Rice KC, Cheng K, Clark DJ, Kingery WS
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Journal Title
Mol Pain
Volume: 28;8
Pages: 85-99
DOI
Related Report
Peer Reviewed
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[Journal Article] Suppression of ovalbumin-induced allergic diarrhea by diminished intestinal peristalsis in RAMP1-deficient mice2011
Author(s)
Yoshikawa R, Mikami N, Otani I, Kishimoto T, Nishioka S, Hashimoto N, Miyagi Y, Takuma Y, Sueda K, Fukada S, Yamamoto H, Tsujikawa K
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Journal Title
Biochem Biophys Res Commun.
Volume: 410
Issue: 3
Pages: 389-393
DOI
Related Report
Peer Reviewed
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[Journal Article] Calcitonin Gene-Related Peptide is an Important Regulator of Cutaneous Immunity: Effect on Dendritic Cell and T Cell Functions2011
Author(s)
Mikami N, Matsushita H, Kato T, Kawasaki R, Sawazaki T, Kishimoto T, Ogitani Y, Watanabe K, Miyagi Y, Sueda K, Fukada S, Yamamoto H, Tsujikawa K
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Journal Title
J. Immunol.
Volume: 186
Issue: 12
Pages: 6886-93
DOI
Related Report
Peer Reviewed
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