| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
We developed ELISA system for measurement of serum tenascin-X (TNX) concentration and performed proteomic analysis of vascular lesion tissues and sera in patients with vascular diseases. In calcified aortic valve (CAV) tissues, TNX showed the greatest decrease in expression compared to normal adjacent tissues. Furthermore, fifty-eight proteins including tenascin-C (TNC) in which expression patterns were distinct between abdominal aortic aneurysm (AAA) and thoracic aortic aneurysms (TAA) were found among 121 differentially expressed proteins identified in both of AAA and TAA compared to normal adjacent tissues.
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