Identification of multidrug resistance mechanisms in Klebsiella pneumoniae and analysis of the function of these gene products.
| Project/Area Number |
22590064
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Okayama University |
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Principal Investigator |
OGAWA Wakano 岡山大学, 大学院・医歯薬学総合研究科, 助教 (90397878)
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| Research Collaborator |
KURODA Teruo 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (80304327)
TSUCHIYA Tomofusa 立命館大学, 薬学部, 教授 (80012673)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 細胞生物学 / 多剤排出ポンプ / 肺炎桿菌 / RND / 多剤耐性菌 |
|---|
| Research Abstract |
Of twelve multidrug resistant mutants from K. pneumoniae ATCC10031, we revealed that the expression of a multidrug efflux pump gene, kexDwas increased in eight mutants. We also identified that two mutants whose expression of kexGHwas increased and the expression of kexABor kexF, was respectively increased in the other two mutants. Especially, 3kbp of deletion in the upstream of kexFwas confirmed in the overexpressing mutant of kexF, and it was thought that the deletion caused the multidrug resistant phenotype.
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Report
(4 results)
Research Products
(40 results)
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[Journal Article] S-nitrosated α-1-acid glycoprotein kills drug-resistant bacteria and aids survival in sepsis2013
Author(s)
Watanabe K, Ishima Y, Akaike T, Sawa T, Kuroda T, Ogawa W, Watanabe H, Suenaga A, Kai T, Otagiri M, Maruyama T
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Journal Title
FASEB J
Volume: 27(1)
Pages: 391-8
Related Report
Peer Reviewed
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[Journal Article] S-nitrosylated a-l-acid glycoprotein kills drug-resistant bacteria and aids survival in sepsis2013
Author(s)
Watanabe K, Ishima Y, Akaike T, Sawa T, Kuroda T, Ogawa W, Watanabe H, Suenaga A, Kai T, Otagiri M, and Maruyama T.
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Journal Title
FASEB J
Volume: 27
Issue: 1
Pages: 391-398
DOI
Related Report
Peer Reviewed
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[Presentation] Novel 2",3",4",6"-o-substituted quercetin-3-o-galactosides and glucosides analogous as potent anti-MRSA and anti-VRE agents : Design, synthesis, sar and in-vitro assessment2010
Author(s)
Abugafar M.L.Hossion, Rafiya K.Kandahary, Tomofusa Tsuchiya, Wakano Ogawa, Yoshito Zamami, Kenji Sasakia
Organizer
XXIVth European Colloquium on Heterocyclic Chemistry (ECHC-2010)
Place of Presentation
Vienna University of Technology Vienna (Austria)
Related Report
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