| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Research Abstract |
Of twelve multidrug resistant mutants from K. pneumoniae ATCC10031, we revealed that the expression of a multidrug efflux pump gene, kexDwas increased in eight mutants. We also identified that two mutants whose expression of kexGHwas increased and the expression of kexABor kexF, was respectively increased in the other two mutants. Especially, 3kbp of deletion in the upstream of kexFwas confirmed in the overexpressing mutant of kexF, and it was thought that the deletion caused the multidrug resistant phenotype.
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