Characterization of a novel protein which inhibits adipocytes differentiation
| Project/Area Number |
22590066
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | The University of Tokushima |
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Principal Investigator |
YAMAZAKI Naoshi 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 准教授 (20271083)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 薬学 / 発生・分化 / 蛋白質 |
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| Research Abstract |
Two kinds of adipose tissues are known to exist in mammals; white and brown adipose tissue. The physiological role of white adipose tissue is storage of bioenergy in the form of fat. Unlike white adipose tissue, the role of brown adipose tissue is dissipation of energy as heat, which prevents mammals from excess storage of energy. We obtained a cDNA encoding a novel protein which abundantly expressed in brown adipose tissue. The putative SH3 domain located on the C-terminal region of this protein can bind dynamin, and it is suggested that the binding of this protein to dynamininhibits endocytosis process. When this protein was overexpressed in preadipocytes, differentiation to mature adipocytes was inhibited. These results suggest that a novel protein abundantly expressed in brown adipose tissue regulates dynamin-mediated endocytosis and its overexpression inhibits adipocytes differentiation.
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Report
(4 results)
Research Products
(11 results)
