Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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Research Abstract |
A systemic RNAi screening methods was developed for searching genetic factors involved in the formation and maturation of novel lysosome-related intestinal granules in Caenorhabditis elegans. The screening system identified various types of genes which affect the intestinal granular formationand maturation. Genetic and biochemical interaction between HAF-4 and HAF-9, the first two identified ABC transporter genes to be required for the intestinal granular formation, was also analyzed.
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