| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
This project had started to elucidate the mechanisms of the inhibitory effects of indomethacin on arachidonic acid uptake. In this project, we have elucidated the detailed mechanisms of the uptake of arachidonic acid as well as the antagonistic effect on human EP2 receptors by indomethacin treatments in human colon cancer cells. Additionally, we have shown that indomethacin can induce epithelial-mesenchymal transition in human lung cancer cells. Moreover, we have indicated that indomethacin could reduce the newly synthesis of the triglyceride in mouse adipocyte. Since we have already started to investigate the effects of newly synthesized indole-compounds on cancer cells, we believe that the findings we have obtained through the project can be applied to the future project for finding novel drugs for cancer therapy.
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