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Modulation of proliferation and differentiation capacitiesby solute carrier transporters in neural progenitor cells

Research Project

Project/Area Number 22590081
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Biological pharmacy
Research InstitutionKanazawa University

Principal Investigator

NAKAMICHI Noritaka  金沢大学, 薬学系, 准教授 (10401895)

Co-Investigator(Kenkyū-buntansha) KATO Yukio  金沢大学, 薬学系, 教授 (30251440)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords脳・神経 / 脳神経疾患 / 神経科学 / 薬理学 / 輸送担体
Research Abstract

To clarify the physiological role of solute carrier (SLC) transporters expressed in neural progenitor cells (NPCs), we examined effects of SLC transporters on proliferation and differentiation capacities in NPCs. As a result, it was suggested that carnitine/organic cation transporter OCTN1/SLC22A4 may be primary organic cation transporter in NPCs, and may suppress proliferation and promote neuronal differentiation of NPCs via uptake of the antioxidant ergothioneine.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (82 results)

All 2013 2012 2011 2010 Other

All Journal Article (20 results) (of which Peer Reviewed: 20 results) Presentation (58 results) Remarks (4 results)

  • [Journal Article] Role of organic cation/carnitine transporter 1 in uptake of phenformin and inhibitory effect on complex I respiration in mitochondria2013

    • Author(s)
      hitara, Y., Nakamichi, N., Norioka, M., Shima, h., Kato, Y., Horie, T
    • Journal Title

      in uptake of phenformin and in mitochondria

      Volume: 132 Issue: 1 Pages: 32-42

    • DOI

      10.1093/toxsci/kfs330

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] TP binding cassette transporters in two distinct compartments of skin contribute to transdermal absorption of a typical substrate2013

    • Author(s)
      Hashimoto, N., Nakamichi, N., Uwafuji, S., Yoshida, K., Sugiura, T., Tsuji, A., Kato, Y.
    • Journal Title

      J. Control. Release

      Volume: 165 Issue: 1 Pages: 54-61

    • DOI

      10.1016/j.jconrel.2012.10.011

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pharmacokinetic modeling of hepatocyte growth factor in experimental animals and humans2013

    • Author(s)
      Tomoko Sugiura et al.
    • Journal Title

      J. Pharm. Sci.

      Volume: 102(1) Issue: 1 Pages: 237-249

    • DOI

      10.1002/jps.23337

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional expression of carnitine/organic cation transporter OCTN1 in mouse brain neurons: Possible involvement in neuronal differentiation2012

    • Author(s)
      Nakamichi, N., Taguchi, T., Hosotani, H., Wakayama, T., Shimizu, T., Sugiura, T., Iseki, S., Kato, Y
    • Journal Title

      Neurochem. Int

      Volume: 61 Issue: 7 Pages: 1121-1132

    • DOI

      10.1016/j.neuint.2012.08.004

    • NAID

      120004966621

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Promotion of both proliferation and differentiation in pluripotent P19 cells with stable overexpression of the glutamine transporter Slc38a12012

    • Author(s)
      Masato Ogura et al.
    • Journal Title

      PLoS ONE

      Volume: 7(10) Issue: 10 Pages: e48270-e48270

    • DOI

      10.1371/journal.pone.0048270

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Promoted neuronal differentiation after activation of alpha4/beta2 nicotinic acetylcholine receptors in undifferentiated neural progenitors2012

    • Author(s)
      Takeshi Takarada, Noritaka Nakamichi, Seiya Kitajima, Ryo Fukumori, Ryota Nakazato, Nguyen Quynh Le, Yeong-Hun Kim, Koichi Fujikawa, Miki Kou and Yukio Yoneda
    • Journal Title

      PLoS ONE

      Volume: 7 Issue: 10 Pages: e46177-e46177

    • DOI

      10.1371/journal.pone.0046177

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Possible neuroprotective property of nicotinic acetylcholine receptors in association with predominant upregulation of glial cell line-derived neurotrophic factor in astrocytes.2012

    • Author(s)
      Takeshi Takarada, Noritaka Nakamichi, Hirofumi Kawagoe, Masato Ogura, Ryo Fukumori, Ryota Nakazato, Koichi Fujikawa, Miki Kou and Yukio Yoneda
    • Journal Title

      J. Neurosci. Res

      Volume: 90(11) Issue: 11 Pages: 2074-2085

    • DOI

      10.1002/jnr.23101

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Delayed Mitochondrial Membrane Potential Disruption by ATP in Cultured Rat Hippocampal Neurons Exposed to <I>N</I>-Methyl-D-Aspartate2012

    • Author(s)
      Fujikawa K, Nakamichi N, Kato S, Fukumori R, Hida M, Takarada T & YonedaY
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 119 Issue: 1 Pages: 20-29

    • DOI

      10.1254/jphs.12034FP

    • NAID

      10030760182

    • ISSN
      1347-8613, 1347-8648
    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transferrin receptor-1 suppresses neurite outgrowth in neuroblastoma Neuro2A cells2011

    • Author(s)
      Yukary Nakamura, Noritaka Nakamichi, Takeshi Takarada, Kiyokazu Ogita, Yukio Yoneda
    • Journal Title

      Neurochem.Int.

      Volume: 60 Issue: 5 Pages: 448-457

    • DOI

      10.1016/j.neuint.2011.08.018

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DZK1 regulates breast cancer resistance protein in small intestine2011

    • Author(s)
      Shimizu, T., Sugiura, T., Wakayama, T.,Kijima, A., Nakamichi, N., Iseki, S.,Silver, D.L., Kato, Y
    • Journal Title

      Drug Metab. Dispos

      Volume: 39 Issue: 11 Pages: 2148-2154

    • DOI

      10.1124/dmd.111.040295

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pharmacokinetics and hepatic uptake of eltrombopag, a novel platelet-increasing agent2011

    • Author(s)
      Takeuchi, K., Sugiura, T., Umeda, S.,Matsubara, K., Horikawa, M., Nakamichi, N., Silver, D.L., Ishiwata, N., Kato, Y
    • Journal Title

      Drug Metab. Dispos

      Volume: 39 Issue: 6 Pages: 1088-1096

    • DOI

      10.1124/dmd.110.037960

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A pivotal role of mitochondrial free calcium in neurotoxicity mediated by N-methyl-D-aspartate receptors in cultured rat hippocampal neurons2011

    • Author(s)
      Yuki Kambe
    • Journal Title

      Neurochem Int

      Volume: 59 Issue: 1 Pages: 10-20

    • DOI

      10.1016/j.neuint.2011.03.018

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Exacerbated vulnerability to oxidative stress in astrocytic C6 glioma cells with stableoverexpression of the glutamine transporter slc38a12011

    • Author(s)
      Masato Ogura, et al.
    • Journal Title

      Neurochemistry International

      Volume: 58(4) Pages: 504-511

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gradual downregulation of protein expression of the partner GABABR2 subunit duringpostnatal brain development inmice defective of GABA_BR1 subunit2011

    • Author(s)
      Masaki Fukui, et al.
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 115(1) Pages: 45-55

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional expression of carnitine/organic cation transporter OCTN1/SLC22A4 in mouse small intestine and liver2010

    • Author(s)
      Sugiura, T., Kato, S., Shimizu, T.,Wakayama, T., Nakamichi, N., Kubo, Y.,Iwata, D., Suzuki, K., Soga, T., Asano, M., Iseki, S., Tamai, I., Tsuji, A., Kato, Y.
    • Journal Title

      Drug Metab. Dispos

      Volume: 38 Issue: 10 Pages: 1665

    • DOI

      10.1124/dmd.110.032763

    • URL

      https://pure.teikyo.jp/en/publications/bb9fb9c4-e10f-43cb-8f96-ff99ebd5fa95

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Preferential inhibition by anti-diarrheic 2-methoxy-4-methylphenol of Ca2+influx across acquired N-methyl-D-aspartate receptor channels composed of NR1/NR2B subunit assembly2010

    • Author(s)
      Nakamichi, N., Fukumori, R., Takarada, T., Kambe, Y., Yamamoto, T., Matsushima, N., Moriguchi, N., Yoneda, Y
    • Journal Title

      J. Neurosci. Res

      Volume: 88 Issue: 11 Pages: 2483-2493

    • DOI

      10.1002/jnr.22399

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] PDZK1 regulates organic anion transporting polypeptide Oatpla in mouse smallintestine2010

    • Author(s)
      Tomoko Sugiura, et al.
    • Journal Title

      Drug Metabolism and Pharmacokinetics

      Volume: 25(6) Pages: 588-598

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Requirement of both NR3A and NR3B subunits for dominant negative properties on Ca^<2+> mobilization mediated by acquired N-methyl-D-aspartate receptor channels intomitochondria2010

    • Author(s)
      Ryo Fukumori, et al.
    • Journal Title

      Neurochemistry International

      Volume: 57(7) Pages: 730-737

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional Expression of Carnitine/Organic Cation Transporter OCTN I/SLC22A4 inmouse small intestine and liver2010

    • Author(s)
      Tomoko Sugiura, et al.
    • Journal Title

      Drug Metabolism and Disposition

      Volume: 38(10) Pages: 1665-1672

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preferential inhibition by antidiarrheic 2-methoxy-4-methylphenol of Ca^<2+>influx across acquired N-methyl-D-aspartate receptor.channels composed of NR1/NR2B subunitassembly2010

    • Author(s)
      Noritaka Nakamichi, et al.
    • Journal Title

      Journal of Neuroscience Research

      Volume: 88(11) Pages: 2483-2493

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] odulation of proliferation and differentiation activity by solute carrier OCTN1/SLC22A4 in neural progenitor cells2013

    • Author(s)
      Nakamichi, N., Ishimoto, T., Hosotani,H., Sugiura, T., Kato, Y
    • Organizer
      24th Biennial Meeting ISN-ASN
    • Place of Presentation
      Cancun Convention Center(Mexico)
    • Year and Date
      2013-04-24
    • Related Report
      2012 Final Research Report
  • [Presentation] 中枢神経系疾患の薬物治療における膜輸送体OCTN1/SLC22A4の役割2013

    • Author(s)
      中道 範隆, 杉浦 智子, 加藤 将夫
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2013-03-30
    • Related Report
      2012 Final Research Report
  • [Presentation] 神経幹細胞における膜輸送体OCTN1の機能的発現と細胞増殖に及ぼす役割.2013

    • Author(s)
      中道 範隆, 石本 尚大, 細谷 拓史, 杉浦智子, 加藤 将夫
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡国際会議場(福岡県)
    • Year and Date
      2013-03-23
    • Related Report
      2012 Final Research Report
  • [Presentation] 中枢神経系疾患の薬物治療における膜輸送体OCTN1/SLC22A4の役割2013

    • Author(s)
      中道 範隆 et al.
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 異物排出トランスポーターMrp阻害剤による神経芽腫細胞株の選択的増殖抑制2013

    • Author(s)
      中道 範隆 et al.
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 神経幹細胞における膜輸送体OCTN1の機能的発現と細胞増殖に及ぼす役割2013

    • Author(s)
      中道 範隆 et al.
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡国際会議場(福岡県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Regulation of maturation by solute carrier OCTN1/SLC22A4 in mouse cortical neurons2012

    • Author(s)
      Nakamichi, N., Hosotani, H., Taguchi,T., Sugiura, T., Kato, Y
    • Organizer
      11th Biennial Meeting of APSN and 55th Meeting of JSN
    • Place of Presentation
      Kobe International Conference Center(Hyogo)
    • Year and Date
      2012-10-02
    • Related Report
      2012 Final Research Report
  • [Presentation] Suppression of proliferation by carnitine/organic cation transporter OCTN1 (SLC22A4) in neural progenitor cells2012

    • Author(s)
      Ishimoto, T., Nakamichi, N., Hosotani,H., Sugiura, T., Kato, Y
    • Organizer
      11th Biennial Meeting of APSN and 55th Meeting of JSN, Kobe International
    • Place of Presentation
      Conference Center (Hyogo)
    • Year and Date
      2012-10-02
    • Related Report
      2012 Final Research Report
  • [Presentation] OCTN1/SLC22A4が神経細胞の増殖・分化に及ぼす影響2012

    • Author(s)
      中道 範隆, 若山 友彦, 杉浦 智子, 井関尚一, 加藤 将夫
    • Organizer
      第7回トランスポーター研究会年会
    • Place of Presentation
      京都大学農学部(京都府)
    • Year and Date
      2012-06-10
    • Related Report
      2012 Final Research Report
  • [Presentation] 膜輸送体OCTN1によるマウス神経芽腫細胞株Neuro2aの分化抑制2012

    • Author(s)
      中道 範隆, 細谷 拓史, 田口 貴之, 杉浦智子, 加藤 将夫
    • Organizer
      第85回日本薬理学会年会,国立京都国際会館
    • Place of Presentation
      京都府
    • Year and Date
      2012-03-16
    • Related Report
      2012 Final Research Report
  • [Presentation] 新規血小板増多剤Eltrombopagと臨床併用薬とのトランスポーターを介した薬物間相互作用2012

    • Author(s)
      杉浦 智子 et al.
    • Organizer
      第33回日本臨床薬理学会学術総会
    • Place of Presentation
      沖縄コンベンションセンター(沖縄県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Interaction of breast cancer resistance protein (BCRP/ABCG2) with PDZ adaptor PDZK1 and therapeutic agents in small intestine2012

    • Author(s)
      Takuya Shimizu et al.
    • Organizer
      Globalization of Pharmaceutics Education Network Meeting 2012
    • Place of Presentation
      Monash University (Melbourne)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Association of OCTN1/SLC22A4 with activation of hepatic stellate cells2012

    • Author(s)
      Shiori Kawabata et al.
    • Organizer
      日本薬物動態学会第27回年会
    • Place of Presentation
      タワーホール船堀(東京都)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Involvement of solute carrier OCTN1/SLC22A4 in intracerebral distribution of drugs acting on the central nervous system2012

    • Author(s)
      Keigo Nakayama et al.
    • Organizer
      日本薬物動態学会第27回年会
    • Place of Presentation
      タワーホール船堀(東京都)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 異物排出ABCトランスポーターを標的とした外用添加剤による皮内動態制御2012

    • Author(s)
      及川 真志 et al.
    • Organizer
      第124回日本薬学会北陸支部会
    • Place of Presentation
      富山大学杉谷キャンパス(富山県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 膜輸送体OCTN1による未分化神経細胞モデルNeuro2aの分化制御2012

    • Author(s)
      木下 直紀 et al.
    • Organizer
      第124回日本薬学会北陸支部会
    • Place of Presentation
      富山大学杉谷キャンパス(富山県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] カルニチン/有機カチオントランスポーターOCTN1 の肝臓での機能的発現と肝線維化に及ぼす影響2012

    • Author(s)
      杉浦 智子 et al.
    • Organizer
      第34回生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      京都大学薬学部(京都府)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Gastrointestinal absorption of metformin regulated by carnitine/organic cation transporter OCTN1 (SLC22A4)2012

    • Author(s)
      Satoshi Asano et al.
    • Organizer
      18th North American Regional ISSX Meeting
    • Place of Presentation
      Hilton Anatole Dallas Hotel (Dallas)
    • Related Report
      2012 Annual Research Report
  • [Presentation] OCTN1/SLC22A4 is functionally expressed in hepatic non-parenchymal cells2012

    • Author(s)
      Ryuichi Harada et al.
    • Organizer
      18th North American Regional ISSX Meeting
    • Place of Presentation
      Hilton Anatole Dallas Hotel (Dallas)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Regulation of maturation by solute carrier OCTN1/SLC22A4 in mouse cortical neurons2012

    • Author(s)
      Noritaka Nakamichi et al.
    • Organizer
      11th Biennial Meeting of APSN and 55th Meeting of JSN
    • Place of Presentation
      Kobe International Conference Center (Kobe)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Suppression of proliferation by carnitine/organic cation transporter OCTN1 (SLC22A4) in neural progenitor cells2012

    • Author(s)
      Takahiro Ishimoto et al.
    • Organizer
      11th Biennial Meeting of APSN and 55th Meeting of JSN
    • Place of Presentation
      Kobe International Conference Center (Kobe)
    • Related Report
      2012 Annual Research Report
  • [Presentation] ATP-induced delay of mitochondrial membrane potential disruption by NMDA in cultured rat hippocampal neurons2012

    • Author(s)
      Koichi Fujikawa et al.
    • Organizer
      11th Biennial Meeting of APSN and 55th Meeting of JSN
    • Place of Presentation
      Kobe International Conference Center (Kobe)
    • Related Report
      2012 Annual Research Report
  • [Presentation] PDZ adaptor PDZK1 is a functional regulator of breast cancer resistance protein (BCRP/ABCG2) in small intestine2012

    • Author(s)
      Takuya Shimizu et al.
    • Organizer
      International Symposium on Epithelial Barrier and Transport 2012
    • Place of Presentation
      Ritsumeikan University (Kusatsu)
    • Related Report
      2012 Annual Research Report
  • [Presentation] OCTN1/SLC22A4が神経細胞の増殖・分化に及ぼす影響2012

    • Author(s)
      中道 範隆 et al.
    • Organizer
      第7回トランスポーター研究会年会
    • Place of Presentation
      京都大学農学部(京都府)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 皮膚組織に発現するP-gpおよびBCRPを標的とした基質の皮内動態制御2012

    • Author(s)
      橋本 直人 et al.
    • Organizer
      日本薬剤学会第27年会
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 血小板増加薬Eltrombopagと併用薬との薬物間相互作用機構2012

    • Author(s)
      竹内和也, et al
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      北海道大学(北海道)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 膜輸送体OCTN1によるマウス神経芽腫細胞株Neuro2aの分化抑制2012

    • Author(s)
      中道範隆, et al
    • Organizer
      第85回日本薬理学会年会
    • Place of Presentation
      国立京都国際会館(京都府)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Involvement of OCTN1/SLC22A4 in uptake of ergothioneine and neurite outgrowth in murine neurons2011

    • Author(s)
      Hosotani, H., Nakamichi, N., Taguchi,T., Wakayama, T., Sugiura, T., Iseki, S.,Kato, Y
    • Organizer
      日本薬物動態学会第26回年会
    • Place of Presentation
      広島国際会議場(広島県)
    • Year and Date
      2011-11-18
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] ニコチンによる神経幹細胞の機能制御2011

    • Author(s)
      北島聖也, et al
    • Organizer
      第120回日本薬理学会近畿部会
    • Place of Presentation
      ホテルグランビア京都(京都府)
    • Year and Date
      2011-11-11
    • Related Report
      2011 Annual Research Report
  • [Presentation] マウス神経細胞におけるカルニチン/有機カチオントランスポーターOCTN1の機能的発現2011

    • Author(s)
      中道 範隆, 田口 貴之, 細谷 拓史, 杉浦智子, 加藤 将夫
    • Organizer
      第54回日本神経化学会大会
    • Place of Presentation
      山代温泉 瑠璃光(石川県)
    • Year and Date
      2011-09-28
    • Related Report
      2012 Final Research Report
  • [Presentation] Inhibitory effect of uremic toxins on hepatic uptake of SN-382011

    • Author(s)
      Saki Umeda, et al
    • Organizer
      日本薬物動態学会第26回年会
    • Place of Presentation
      広島国際会議場(広島県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Involvement of OCTN1/Octn1 in phenformin-induced mitochondrial toxicity2011

    • Author(s)
      Natsuko Kikuta, et al
    • Organizer
      日本薬物動態学会第26回年会
    • Place of Presentation
      広島国際会議場(広島県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Physiologically-based pharmacokinetic model for hepatocyte growth factor2011

    • Author(s)
      Kazusa Sano, et al
    • Organizer
      日本薬物動態学会第26回年会
    • Place of Presentation
      広島国際会議場(広島県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] PDZ adaptor PDZK1 regulates expression of breast cancer resistance protein (BCRP) on apical membrane in small intestine2011

    • Author(s)
      Takuya Shimizu, et al
    • Organizer
      日本薬物動態学会第26回年会
    • Place of Presentation
      広島国際会議場(広島県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Involvement of carnitine/organic cation transporter OCTN1 in gastrointestinal absorption of metformin2011

    • Author(s)
      Noritaka Nakamichi, et al
    • Organizer
      日本薬物動態学会第26回年会
    • Place of Presentation
      広島国際会議場(広島県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Functional and localization of P-glycoprotein and brest cancer resistance protein expressed in mouse skin2011

    • Author(s)
      Naoto Hashimoto, et al
    • Organizer
      日本薬物動態学会第26回年会
    • Place of Presentation
      広島国際会議場(広島県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Involvement of OCTN1 in dimethylnitrosamine (DMN)-induced liver fibrosis2011

    • Author(s)
      Ryuichi Harada, et al
    • Organizer
      日本薬物動態学会第26回年会
    • Place of Presentation
      広島国際会議場(広島県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Evaluation of possible drug-drug interaction between eitrotnbopag and coadministe red drugs via hepatic transporters2011

    • Author(s)
      Kazuki Matsubara, et al
    • Organizer
      日本薬物動態学会第26回年会
    • Place of Presentation
      広島国際会議場(広島県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] マウス神経細胞におけるカルニチン/有機カチオントランスポーターOCTN1の機能的発現2011

    • Author(s)
      中道範隆, et al
    • Organizer
      第54回日本神経化学会大会
    • Place of Presentation
      山代温泉瑠璃光(石川県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] カルニチン/有機カチオントランスポーターOCTN1による神経突起伸展制御2011

    • Author(s)
      細谷拓史, et al
    • Organizer
      第54回日本神経化学会大会
    • Place of Presentation
      山代温泉瑠璃光(石川県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Phenforminにより引き起こされるミトコンドリア障害に対するOCTN1/Octn1の関与2011

    • Author(s)
      設楽悦久, et al
    • Organizer
      第6回トランスポーター研究会年会
    • Place of Presentation
      東北大学(宮城県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] PDZK1による消化管排出トランスポーターBCRPの制御と薬物動態への影響2011

    • Author(s)
      杉浦智子, et al
    • Organizer
      第6回トランスポーター研究会年会
    • Place of Presentation
      東北大学(宮城県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] octn1/slc22a4遺伝子欠損マウスを用いたDMN誘発性肝線維化の解析2011

    • Author(s)
      原田龍一, et al
    • Organizer
      第6回トランスポーター研究会年会
    • Place of Presentation
      東北大学(宮城県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] PDZ adaptor PDZK1 regulates breast cancer resistance protein (ABCG2) in small intestine2011

    • Author(s)
      Takuya Shimizu, et al
    • Organizer
      日本分子生物学会第11回春季シンポジウム
    • Place of Presentation
      石川県立音楽堂(石川県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] トランスポーターoctn1遺伝子欠損マウスを用いたDMN誘発性肝線維化の解析2011

    • Author(s)
      杉浦智子, et al
    • Organizer
      日本薬剤学会第26年会
    • Place of Presentation
      タワーホール船堀(東京都)
    • Related Report
      2011 Annual Research Report
  • [Presentation] マウス皮膚に発現するP-gp/BCRPの機能と炎症時における役割2011

    • Author(s)
      橋本直人, et al
    • Organizer
      日本薬剤学会第26年会
    • Place of Presentation
      タワーホール船堀(東京都)
    • Related Report
      2011 Annual Research Report
  • [Presentation] II型糖尿病治療薬metforminの体内動態に及ぼすカルニチン/有機カチオントヲンスポーターOCTN1の関与2011

    • Author(s)
      島広世, et al.
    • Organizer
      貨本薬学会第131年会
    • Place of Presentation
      誌上開催
    • Related Report
      2010 Annual Research Report
  • [Presentation] Phenforminによる毒性に対するミトコンドリア輸送担体の関与の解明2011

    • Author(s)
      則岡美咲, et al.
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      誌上開催
    • Related Report
      2010 Annual Research Report
  • [Presentation] マウス脳に発現するカルニチン/有機カチオントランスポーターOCTN1の機能解析2011

    • Author(s)
      中道範隆, et al.
    • Organizer
      第84回日本薬理学会年会
    • Place of Presentation
      誌上開催
    • Related Report
      2010 Annual Research Report
  • [Presentation] マウス脳におけるカルニチン/有機カチオントランスポーターOCTN1(SLC22A4)の役割2010

    • Author(s)
      中道 範隆, 田口 貴之, 山田 寛哉, 杉浦智子, 加藤 将夫
    • Organizer
      第32回生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      富山国際会議場(富山県)
    • Year and Date
      2010-11-30
    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Presentation] マウス脳に発現するカルニチン/有機カチオントランスポーターOCTN1の生理的機能解明2010

    • Author(s)
      田口貴之, et al.
    • Organizer
      第122回日本薬学会北陸支部会
    • Place of Presentation
      北陸大学薬学部(石川県)
    • Year and Date
      2010-11-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] Mitochondrial uptake of organic cations as one of determinants of phenformiminduced lactic acidosis2010

    • Author(s)
      Misaki Norioka, et at.
    • Organizer
      第4回次世代を担う若手医療薬科学シンポジウム
    • Place of Presentation
      東京大学本郷キャンパス(東京都)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Functional expression of carnitine/organic cation transporter OCTN1 (SLC22A4) in mouse brain2010

    • Author(s)
      Takayuki Taguchi, et al.
    • Organizer
      日本薬物動態学会第25回年会
    • Place of Presentation
      大宮ソニックシティ(埼玉県)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Characterization of hepatic uptake mechanism for eitrombopag, a novel platelet increasing agent2010

    • Author(s)
      Kazuya Takeuchi, et al.
    • Organizer
      日本薬物動態学会第25回年会
    • Place of Presentation
      大宮ソニックシティ(埼玉県)
    • Related Report
      2010 Annual Research Report
  • [Presentation] グリア細胞におけるグルタミントランスポーターの細胞内局在2010

    • Author(s)
      佐古彩, et al.
    • Organizer
      第40回日本神経精神薬理学会年会
    • Place of Presentation
      仙台国際センター(宮城県)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 静磁場曝露神経系前駆細胞における神経細胞分化能促進2010

    • Author(s)
      中里亮太, et al.
    • Organizer
      Neuro2010
    • Place of Presentation
      神戸コンベンションセンター(兵庫県)
    • Related Report
      2010 Annual Research Report
  • [Presentation] PDZアダプターPDZK1による消化管トランスポーターOATPIAの剃御2010

    • Author(s)
      木嶋愛, et al.
    • Organizer
      第5回トランスポーター研究会年会
    • Place of Presentation
      東京医科大学病院(東京都)
    • Related Report
      2010 Annual Research Report
  • [Presentation] アダプタータンパク質による消化管トランスポーターの機能・発境舗御と薬物動態への影響2010

    • Author(s)
      杉浦智子, et al.
    • Organizer
      第5回トランスポーター研究会年会
    • Place of Presentation
      東京医科大学病院(東京都)
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.p.kanazawa-u.ac.jp/~bunyaku/

    • Related Report
      2012 Final Research Report
  • [Remarks] 分子薬物治療学研究室

    • URL

      http://www.p.kanazawa-u.ac.jp/~bunyaku/

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.p.kanazawa-u.ac.jp/~bunyaku/

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.p.kanazawa-u.ac.jp/~bunyaku/

    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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