| Project/Area Number |
22590085
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
|
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| Research Institution | Health Sciences University of Hokkaido |
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Principal Investigator |
|
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| Co-Investigator(Kenkyū-buntansha) |
MACHIDA Takuji 北海道医療大学, 薬学部, 講師 (90433424)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | セロトニン(5-HT) / 一酸化窒素(NO) / NO 合成酵素 / 消化管障害 / 抗がん剤 / エンテロクロマフィン細胞 / セロトニン / 一酸化窒素 / サブスタンスP / 異味症 / メトトレキサート / 制がん剤誘起性嘔吐 / トリプトファン水酸化酵素 / ラット |
|---|
| Research Abstract |
The roles of nitric oxide (NO) in abnormal intestinal serotonin metabolism have been investigated using a model rat of intestinal damage induced by anti-cancer drugs. Among four drugs tested, methotrexate (MTX) specifically caused an increase in NO synthesis, which in turn induced a hyperplasia of ileal enterochromaffin cells and an increase in serotonin synthesis. The stimulation of intestinal NO production did not correlate with the emetogenicity and pro-inflammatory property of anti-cancer drugs.
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