Neurophysiological and immunohistochemical studies of IgG anti-GM1 monoclonal antibody on neuromuscular transmission
| Project/Area Number |
22590087
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Showa Pharmaceutical University |
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Principal Investigator |
TAGUCHI Kyoji 昭和薬科大学, 薬学部, 教授 (70171593)
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| Co-Investigator(Renkei-kenkyūsha) |
HORIGUCHI Yoshie 昭和薬科大学, 薬学部, 教授 (70190254)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
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| Keywords | ギラン・バレー症候群 / モノクローナル IgG 抗 GM1 抗体 / カルシウムチャネル / ギランバレー症候群 / 抗ガングリオシド抗体 / IgG抗GM1抗体 / IgG抗GalNAc-GD1a抗体 / 運動神経末梢 / mouse monoclonal IgG抗GM1抗体 / 自発性筋活動電位 / 電位依存性カルシウムチャネル / ω-agatoxinIVA / ω-conotoxin GVIA / nicardipine / 神経・筋接合部 / anti-neurofilament200 / anti-Syntaxin / α-Bungarotoxin |
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| Research Abstract |
We suggest that the inhibitory effect of IgG anti-GM1 mAb on spontaneous muscle action potentials is related to the GM1 epitope in presynaptic motor nerve terminals at the neuromuscular junctions.
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Report
(4 results)
Research Products
(3 results)
