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Neurophysiological and immunohistochemical studies of IgG anti-GM1 monoclonal antibody on neuromuscular transmission

Research Project

Project/Area Number 22590087
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Biological pharmacy
Research InstitutionShowa Pharmaceutical University

Principal Investigator

TAGUCHI Kyoji  昭和薬科大学, 薬学部, 教授 (70171593)

Co-Investigator(Renkei-kenkyūsha) HORIGUCHI Yoshie  昭和薬科大学, 薬学部, 教授 (70190254)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Keywordsギラン・バレー症候群 / モノクローナル IgG 抗 GM1 抗体 / カルシウムチャネル / ギランバレー症候群 / 抗ガングリオシド抗体 / IgG抗GM1抗体 / IgG抗GalNAc-GD1a抗体 / 運動神経末梢 / mouse monoclonal IgG抗GM1抗体 / 自発性筋活動電位 / 電位依存性カルシウムチャネル / ω-agatoxinIVA / ω-conotoxin GVIA / nicardipine / 神経・筋接合部 / anti-neurofilament200 / anti-Syntaxin / α-Bungarotoxin
Research Abstract

We suggest that the inhibitory effect of IgG anti-GM1 mAb on spontaneous muscle action potentials is related to the GM1 epitope in presynaptic motor nerve terminals at the neuromuscular junctions.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (3 results)

All 2012

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (2 results)

  • [Journal Article] IgG ANTI-GalNAc-GD1a ANTIBODIES BIND TO NEUROMUSCULAR JUNCTIONS OF RAT HEMI-DIAPHRAGM2012

    • Author(s)
      Takumi Nagaoka, Sayako Hotta, Terumasa Chiba, Iku Utsunomiya, Kenji Abe, Hiide Yoshino, Chiaki Koshikawa,Kyoji Taguchi
    • Journal Title

      Muscle and Nerve

      Volume: 46巻 Issue: 5 Pages: 505-710

    • DOI

      10.1002/mus.23385

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Presentation] GalNAc-GD1a及び GM1 のラット横隔膜における免疫組織化学的検討2012

    • Author(s)
      堀田紗綾子、長岡 匠、千葉輝正、宇都宮郁、阿部賢志、田口恭治
    • Organizer
      日本薬学会第132 年会
    • Place of Presentation
      札幌
    • Year and Date
      2012-03-30
    • Related Report
      2012 Final Research Report
  • [Presentation] GalNAc-GD1a及びGM1のラット横隔膜における免疫組織化学的検討2012

    • Author(s)
      田口恭治
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      北海道大学(札幌)
    • Year and Date
      2012-03-29
    • Related Report
      2011 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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