| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Research Abstract |
Neurolathyrism (NL), a motoneuron disease, is caused by the overconsumption of grass pea that is a draught-tolerant crop containing a neurotoxin L-β-ODAP. Under the unavoidable deficiencies of sulfur-containing amino acids and glutathione, I clarified the induction of nonspecific cation channels TRPM2 and 7 in cultured cells and in the spinal cord of a NL-model rat. In the model, there observed the vessel disruption and hemorrhage in the lower spinal cord where heme oxygenase-1 was highly induced to cause pathological changes.
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