Study on pathophysiological mechanism underlying leptin-induced exacerbation of neuropathic pain
| Project/Area Number |
22590090
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Nigata University of Phermacy and Applied Life Sciences |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MAEDA Takehiko 新潟薬科大学, 薬学部, 教授 (50271010)
KISHIOKA Shiroh 和歌山県立医科大学, 医学部, 教授 (60137255)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 疼痛 / クロマチン免疫沈降 / ヌクレオカイン / 神経障害性疼痛 / HMGB1 |
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| Research Abstract |
We studied the mechanism underlying leptin release from adipocytes, which is a mediator for the induction of neuropathic pain underlying of neuropathic pain. The present results indicated that HMGB1, high mobility group box 1 was released from injured peripheral nerve tissue and then, acted on adipocytes to promote leptin release. It was elucidated that HMGB1 was an immediate early mediator for induction of neuropathic pain.
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Report
(4 results)
Research Products
(24 results)
