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Study on pathophysiological mechanism underlying leptin-induced exacerbation of neuropathic pain

Research Project

Project/Area Number 22590090
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Biological pharmacy
Research InstitutionNigata University of Phermacy and Applied Life Sciences

Principal Investigator

OZAKI Masanobu  新潟薬科大学, 薬学部, 教授 (30094650)

Co-Investigator(Kenkyū-buntansha) MAEDA Takehiko  新潟薬科大学, 薬学部, 教授 (50271010)
KISHIOKA Shiroh  和歌山県立医科大学, 医学部, 教授 (60137255)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords疼痛 / クロマチン免疫沈降 / ヌクレオカイン / 神経障害性疼痛 / HMGB1
Research Abstract

We studied the mechanism underlying leptin release from adipocytes, which is a mediator for the induction of neuropathic pain underlying of neuropathic pain. The present results indicated that HMGB1, high mobility group box 1 was released from injured peripheral nerve tissue and then, acted on adipocytes to promote leptin release. It was elucidated that HMGB1 was an immediate early mediator for induction of neuropathic pain.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (24 results)

All 2013 2012 2011 2010 Other

All Journal Article (9 results) (of which Peer Reviewed: 8 results) Presentation (14 results) (of which Invited: 1 results) Remarks (1 results)

  • [Journal Article] The critical role of spinal ceramide in the development of partial sciatic nerve ligation-induced neuropathic pain in mice2012

    • Author(s)
      Kobayashi Y, Kiguchi N, Maeda T, Ozaki M, Kishioka S.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 421 Issue: 2 Pages: 318-322

    • DOI

      10.1016/j.bbrc.2012.03.153

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Epigenetic augmentation of the macrophage inflammatory protein 2/C-X-C chemokine receptor type 2 axis through histone H3 acetylation in injured peripheral nerves elicits neuropathic pain2012

    • Author(s)
      Kiguchi N, et al
    • Journal Title

      J Pharmacol Exp Ther

      Volume: 340 Issue: 3 Pages: 577-587

    • DOI

      10.1124/jpet.111.187724

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Availability of serum corticosterone level for quantitative evaluation of morphine withdrawal in mice2011

    • Author(s)
      Ueno K, Maeda T, Kiguchi N, Kobayashi Y, Ozaki M, Kishioka S.
    • Journal Title

      Drug Discov Ther

      Volume: 5 Pages: 71-75

    • NAID

      130005054697

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed/22466143

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pharmacological relationship between nicotinic and opioid systems in analgesia and corticosterone elevation2011

    • Author(s)
      Yamamoto A
    • Journal Title

      Life Sci

      Volume: 89 Issue: 25-26 Pages: 956-961

    • DOI

      10.1016/j.lfs.2011.10.004

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increment of activated serine/threonine protein phosphatase in brain membrane fraction synchronized with antinociceptive effect of morphine in mice2010

    • Author(s)
      Maeda T, Kiguchi N, Kobayashi Y, Ozaki M, Kishioka S
    • Journal Title

      Biol.Pharm. Bull.

      Volume: 33 Pages: 1011-1014

    • NAID

      130000247970

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed/20522968

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Macrophage inflammatory protein-1α mediates the development of neuropathic pain following peripheral nerve injury through interleukin-1β up-regulation2010

    • Author(s)
      Kiguchi N, Maeda T, et al.
    • Journal Title

      Pain

      Volume: 149(2) Pages: 305-315

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increment of activated serine/threonine protein phosphatase in brain membrane fraction synchronized with antinociceptive effect of morphine in mice2010

    • Author(s)
      Maeda T, et al.
    • Journal Title

      Biol.Pharm.Bull.

      Volume: 33(6) Pages: 1011-1014

    • NAID

      130000247970

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CC-chemokine MIP-1α in the spinal cord contributes to nerve injury-induced neuropathic pain2010

    • Author(s)
      Kiguchi N, Kobayashi Y, Maeda T, et al.
    • Journal Title

      Neurosci.Lett.

      Volume: 484 Pages: 17-21

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] レプチンと神経障害性疼痛2010

    • Author(s)
      前田武彦
    • Journal Title

      医学のあゆみ

      Volume: 233(7) Pages: 565-565

    • Related Report
      2010 Annual Research Report
  • [Presentation] 慢性および難治性疼痛発症機序の解明と創薬に向けて2013

    • Author(s)
      前田武彦,尾崎昌宣
    • Organizer
      日本薬学会第133年会シンポジウム
    • Place of Presentation
      横浜
    • Year and Date
      2013-03-30
    • Related Report
      2012 Final Research Report
  • [Presentation] TRPチャネルを標的とする新規鎮痛機序の解析2013

    • Author(s)
      前田武彦
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 慢性疼痛における脂肪細胞の機能的役割とその制御2011

    • Author(s)
      前田武彦
    • Organizer
      第61回日本薬学会近畿支部総会シンポジウム
    • Place of Presentation
      神戸
    • Year and Date
      2011-10-22
    • Related Report
      2012 Final Research Report
  • [Presentation] 緩和医療における臨床研究・基礎研究とは2011

    • Author(s)
      前田武彦
    • Organizer
      第61回日本薬学会近畿支部総会・大会
    • Place of Presentation
      神戸
    • Year and Date
      2011-10-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] Effect of capsaicin on neuropathic pain through the modulation of interaction of adipocytes and macrophages2011

    • Author(s)
      前田武彦, 他
    • Organizer
      第84回日本薬理学会
    • Place of Presentation
      (誌上開催)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 神経障害性疼痛におけるマクロファージ活性化および脂肪細胞肥大化に及ぼすカプサイシンの影響2010

    • Author(s)
      前田武彦, 他
    • Organizer
      第117回日本薬理学会近畿部会
    • Place of Presentation
      徳島
    • Related Report
      2010 Annual Research Report
  • [Presentation] レプチンの神経障害性疼痛における役割2010

    • Author(s)
      前田武彦, 他
    • Organizer
      第15回アディポサイエンス研究会シンポジウム
    • Place of Presentation
      大阪
    • Related Report
      2010 Annual Research Report
  • [Presentation] 神経障害性疼痛におけるHMGB1の関与2010

    • Author(s)
      前田武彦, 他
    • Organizer
      第31回鎮痛薬・オピオイドペプチドシンポジウム
    • Place of Presentation
      名古屋
    • Related Report
      2010 Annual Research Report
  • [Presentation] 神経障害性疼痛形成におけるMIP-2の役割2010

    • Author(s)
      木口倫一、前田武彦, 他
    • Organizer
      第31回鎮痛薬・オピオイドペプチドシンポジウム
    • Place of Presentation
      名古屋
    • Related Report
      2010 Annual Research Report
  • [Presentation] Macropharge inflammatory protein 1α mediates the development of neuropathic pain following peripheral nerve injury2010

    • Author(s)
      木口倫一、前田武彦, 他
    • Organizer
      Neuro2010
    • Place of Presentation
      神戸
    • Related Report
      2010 Annual Research Report
  • [Presentation] Macrophage inflammatory protein-1α plays a key role in the development of neuropathic pain2010

    • Author(s)
      Kiguchi N, Maeda T, et al.
    • Organizer
      New Perspectives in Neuroscience : Joint Meeting of Young Italian and Japanese Neuroscientists
    • Place of Presentation
      Naples, Italy
    • Related Report
      2010 Annual Research Report
  • [Presentation] Leptin and neuropathic pain2010

    • Author(s)
      Kishioka S, Maeda T
    • Organizer
      Molecular Targets for Novel Pain Therapeutics From basic research to clinical translation
    • Place of Presentation
      Calabria, Italy
    • Related Report
      2010 Annual Research Report
  • [Presentation] Role of macrophage inflammatory protein-1 in the pathogenesis of neuropathic pain2010

    • Author(s)
      Kiguchi N, Maeda T, et al.
    • Organizer
      Molecular Targets for Novel Pain Therapeutics From basic research to clinical translation
    • Place of Presentation
      Calabria, Italy
    • Related Report
      2010 Annual Research Report
  • [Presentation] Macrophage inflammatory protein-1α mediates the pathgenesis of neuropathic pain2010

    • Author(s)
      Kiguchi N, Maeda T, et al.
    • Organizer
      Neuroscience2010
    • Place of Presentation
      San Diego, USA
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.wakayama-med.ac.jp/dept/igakubu/160416/index.html

    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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