The mechanism of hypotension by renin-angiotensin system
| Project/Area Number |
22590093
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Kobe Gakuin University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OKAMOTO Hiroshi 神戸学院大学, 薬学部, 教授 (00028870)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | Rho キナーゼ / アンジオテンシン / チロシンホスファターゼ / 細胞内酸性化 / カルモジュリン / 血管内皮細胞 / Rhoキナーゼ / 一酸化窒素 |
|---|
| Research Abstract |
Vasotone plays an important role in the development of hypertension. In these studies we showed that cell acidification induces the vasolelaxation through production of NO which is vasolelaxation factor. On the other hand, inhibition of the protein tyrosine phosphatases and hypertonic stress induce the vasoconstriction.
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Report
(4 results)
Research Products
(51 results)
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[Journal Article] Boron neutron capture therapy for clear cell sarcoma (CCS): biodistribution study of p-borono-L- phenylalanine in CCS-bearinganimal models.2011
Author(s)
Andoh T, Fujimoto T, Sudo T, Fujita I, Imabori M, Moritake H, Sugimoto T, Sakuma Y, Takeuchi T, Kawabata S, Kirihata M, Akisue T, Yayama K, Kurosaka M, Miyatake S, Fukumori Y, Ichikawa H.
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Journal Title
Appl Radiat Isot.
Volume: 69(12)
Pages: 1721-4
Related Report
Peer Reviewed
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[Journal Article] Boron neutron capture therapy for clear cell sarcoma (CCS) : biodistribution study of p-borono-L-phenylalanine in CCS-bearing animal models2011
Author(s)
Andoh T, Fujimoto T, Sudo T, Fujita I, Imabori M, Moritake H, Sugimoto T, Sakuma Y, Takeuchi T, Kawabata S, Kirihata M, Akisue T, Yayama K, Kurosaka M, Miyatake S, Fukumori Y, Ichikawa H
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Journal Title
Appl Radiat Isot
Volume: 69(12)
Pages: 1721-4
Related Report
Peer Reviewed
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[Presentation] 非晶質ナノシリカはPI3Kシグナルを介する血管弛緩を惹起する2013
Author(s)
古田 拓也, 小野寺 章, 屋山 勝俊, 諸澤 瑛, 田中 敦士, 石井 幸奈,太田 舞子, 本間 安季, 岡本 博, 米村 重信, 堤 康央, 河合 裕一
Organizer
日本薬学会第133年会
Place of Presentation
横浜
Related Report
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[Presentation] ナノマテリアルによる細胞内遊離Ca²⁺の増加は細胞膜上のCa²⁺チャネルに依存する。2013
Author(s)
石井幸奈、古田 拓也, 小野寺 章, 屋山 勝俊, 諸澤 瑛, 田中 敦士, 太田 舞子, 本間 安季, 岡本 博, 米村 重信, 堤 康央, 河合 裕一
Organizer
日本薬学会第133年会
Place of Presentation
横浜
Related Report
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[Presentation] 組織酸性化による血管弛緩機構2011
Author(s)
笹原智也、大庭久明、古賀大介、屋山勝俊、岡本博
Organizer
日本薬学会第131回年会
Place of Presentation
静岡(東日本大震災により誌上開催)
Year and Date
2011-03-30
Related Report
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