Biochemical and histological characterization of MAGI-1 inneuronal tissues.

• Project/Area Number: 22590097
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Biological pharmacy
• Research Institution: Institute for Developmental Research, Aichi Human Service Center
• Principal Investigator: MORISHITA Rika 愛知県心身障害者コロニー発達障害研究所, 神経制御学部, 研究助手 (30393135)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 脳 / 神経細胞 / アダプター分子 / 神経栄養因子 / MAGI-1 / PC12細胞 / 神経突起

Research Abstract

Using the antibody that selectively recognize MAGI-1, we performed biochemical and histological characterization of MAGI-1 in neuronal tissues. We also found that MAGI-1 interacts with p75 NGF receptor (p75NTR) and She phosphotyrosine binding protein, and regulates the NGF dependent neurite outgrowth of PC12 cells.

Research Products

• [Journal Article] Localization of multidomain adaptor proteins, pl40Cap and vinexin, in the pancreatic islet of a spontaneous diabetes mellitus model, Otsuka Long-Evans Tokushima Fatty rats. (2013)
  • Author(s): Yamauchi M, Sudo K, Ito H, Iwamoto I, Morishita R, Murai T, Kajita K, Ishizuka T, Nagata K.
  • Journal Title: Med Mol Morphol. Volume: 46 Pages: 41-48
  • Peer Reviewed
• [Journal Article] Possible role of a septin, SEPT1, in spreading in squamous cell carcinoma DJM-1 cells. (2013)
  • Author(s): Mizutani Y, Ito H, Iwamoto I, Morishita R, Kanoh H, Seishima M, Nagata KI.
  • Journal Title: Biol Chem. Volume: 394 Issue: 2 Pages: 281-290
  • DOI: 10.1515/hsz-2012-0258
  • Peer Reviewed
• [Journal Article] Localization of multidomain adaptor proteins, p140Cap and vinexin, in the pancreatic islet of a spontaneous diabetes mellitus model, Otsuka Long-Evans Tokushima Fatty rats. (2013)
  • Author(s): Yamauchi, M.
  • Journal Title: Med. Mol. Morphol. Volume: 46 Issue: 1 Pages: 41-48
  • DOI: 10.1007/s00795-013-0008-1
  • Peer Reviewed
• [Journal Article] Biochemical and morphological characterization of MAGI-1 in neuronal tissue. (2012)
  • Author(s): Ito H, Morishita R, Sudo K, Nishimura YV, Inaguma Y, Iwamoto I, Nagata KI.
  • Journal Title: J Neurosci Res Volume: 90 Issue: 9 Pages: 1776-1781
  • DOI: 10.1002/jnr.23074
  • Peer Reviewed
• [Journal Article] Cell biological characterization of a multidomain adaptor protein, ArgBP2, in epithelial NMuMG cells, and identification of a novel short isoform. (2012)
  • Author(s): Murase K, Ito H, Kanoh H, Sudo K, Iwamoto I, Morishita R, Soubeyran P, Seishima M, Nagata K.
  • Journal Title: Med Mol Morphol. Volume: 45 Issue: 1 Pages: 22-28
  • DOI: 10.1007/s00795-010-0537-9
  • NAID: 10030573597
  • Peer Reviewed
• [Journal Article] (*equal contribution; #corresponding authors)UV-sensitive photoreceptor protein OPN5 in humans and mice (2011)
  • Author(s): Kojima,D.*#, Mori,S.*, Torii,M.*, Wada,A., Morishita,R. & Fukada,Y.#
  • Journal Title: PLoS One Volume: 6 Issue: 10 Pages: e26388-e26388
  • DOI: 10.1371/journal.pone.0026388
  • Peer Reviewed
• [Journal Article] UV-sensitive photoreceptor protein OPN5 in humans and mice. (2011)
  • Author(s): Kojima, D.
  • Journal Title: PloS One Volume: 6
  • Peer Reviewed
• [Journal Article] Dysbindin-1, WAVE2 and Abi-1 form a complex that regulates dendritic spine formation. (2010)
  • Author(s): Ito H, Morishita R, Shinoda T, Iwamoto I, Sudo K, Okamoto K, Nagata K
  • Journal Title: Mol. Psychiatry Volume: 15 Issue: 10 Pages: 976-986
  • DOI: 10.1038/mp.2010.69
  • Peer Reviewed
• [Journal Article] Septin 14 is involved in cortical neuronal migration via interaction with Septin 4. (2010)
  • Author(s): Shinoda T, Ito H, Sudo K, Iwamoto I, Morishita R, Nagata K
  • Journal Title: Mol. Biol. Cell Volume: 21 Issue: 8 Pages: 1324-1334
  • DOI: 10.1091/mbc.e09-10-0869
  • Peer Reviewed
• [Journal Article] Dysbindin-1, WAVE2 and Abi-1 form a complex that regulates dendritic spine formation. (2010)
  • Author(s): Ito, H.
  • Journal Title: Mol Psychiatry. Volume: VOL.15 Pages: 976-986
  • Peer Reviewed
• [Journal Article] Septin 14 is involved in cortical neuronal migration via interaction with Septin 4. (2010)
  • Author(s): Shinoda, T.
  • Journal Title: Mol Biol Cell. Volume: VOL.21 Pages: 1324-1334
  • Peer Reviewed
• [Presentation] SILl, a causative gene of Marinesco-Sjogren syndrome, plays an essential role in establishing the architecture of the developing cerebral cortex. (2012)
  • Author(s): 永田浩一, 稲熊 裕, 西村嘉晃, 伊東秀記, 鈴木基正, 浜田奈々子, 水野 誠, 岩本郁子, 森下理香, 熊谷俊幸
  • Organizer: 米国細胞生物学会
  • Place of Presentation: モスコーンセンター,サンフランシスコ、米国
  • Year and Date: 2012-12-17
• [Presentation] Dysbindin-1と結合する分子の探索と性状機能解析 (2012)
  • Author(s): 伊東秀記, 森下理香, 岩本郁子, 永田浩一
  • Organizer: 日本生化学会
  • Place of Presentation: 福岡国際会議場、福岡
  • Year and Date: 2012-12-15
• [Presentation] MAGI-1 controls the NGF-activated signal pathway and regulates neurite extension. (2012)
  • Author(s): 伊東秀記, 森下理香, 岩本郁子, 永田浩一
  • Organizer: 日本神経化学会
  • Place of Presentation: 神戸国際会議場、神戸
  • Year and Date: 2012-09-30
• [Presentation] 神経系組織におけるMAGI-1の性状機能解析 (2012)
  • Author(s): 伊東秀記, 森下理香, 岩本郁子, 永田浩一
  • Organizer: 日本臨床分子形態学会
  • Place of Presentation: 高知市文化プラザかるぽーと、高知
  • Year and Date: 2012-09-29
• [Presentation] セプチンSEPTlは有棘細胞癌DTM-1細胞の接着に関与する (2012)
  • Author(s): 永田浩一, 水谷陽子, 伊東秀記, 岩本郁子, 森下理香, 加納宏行, 清島真理子
  • Organizer: 日本臨床分子形態学会
  • Place of Presentation: 高知市文化プラザかるぽーと、高知
  • Year and Date: 2012-09-28
• [Presentation] セプチンSEPT1は有棘細胞癌DJM-1細胞の接着に関与する (2012)
  • Author(s): 永田浩一
  • Organizer: 日本臨床分子形態学会
  • Place of Presentation: 高知市文化プラザかるぽーと（高知）
• [Presentation] 神経系組織におけるMAGI-1の性状機能解析 (2012)
  • Author(s): 伊東秀記
  • Organizer: 日本臨床分子形態学会
  • Place of Presentation: 高知市文化プラザかるぽーと（高知）
  • Invited
• [Presentation] MAGI-1 controls the NGF-activated signal pathway and regulates neurite extension. (2012)
  • Author(s): 伊東秀記
  • Organizer: 日本神経化学会
  • Place of Presentation: 神戸国際会議場（神戸）
• [Presentation] Essential role of SIL1, a causative gene of Marinesco-Sjogren syndrome, in the neuronal migration during corticogenesis. (2012)
  • Author(s): 永田浩一
  • Organizer: Neurosciece 2012
  • Place of Presentation: アーネスト モリアル コンベンションセンター（ニューオリンズ、米国）
• [Presentation] Dysbindin-1と結合する分子の探索と性状機能解析 (2012)
  • Author(s): 伊東秀記
  • Organizer: 日本生化学会
  • Place of Presentation: 福岡国際会議場（福岡）
• [Presentation] SIL1, a causative gene of Marinesco-Sjogren syndrome, plays an essential role in establishing the architecture of the developing cerebral cortex (2012)
  • Author(s): 永田浩一
  • Organizer: 米国細胞生物学会
  • Place of Presentation: モスコーンセンター（サンフランシスコ、米国）
• [Presentation] Functional analysis of dysbindin, a schizophrenia risk factor, in dendritic spine formation. (2011)
  • Author(s): 伊東秀記, 森下理香, 西村嘉晃, 篠田友靖, 岩本郁子, 永田浩一
  • Organizer: 米国細胞生物学会
  • Place of Presentation: コロラドコンペンションセンター、デンバー、米国
  • Year and Date: 2011-12-06
• [Presentation] 神経突起伸長におけるMAGI-1の機能解析 (2011)
  • Author(s): 伊東秀記, 森下理香, 西村嘉晃, 篠田友靖, 岩本郁子, 須藤香織, 永田浩一
  • Organizer: 日本生化学会大会
  • Place of Presentation: 京都国際会館、京都
  • Year and Date: 2011-09-23
• [Presentation] 上皮細胞の極性形成・維持におけるアダプター蛋白質ArgBP2の役割 (2011)
  • Author(s): 村瀬香奈, 伊東秀記, 加納宏行, 須藤香織, 岩本郁子, 森下理香, 清島真理子, 永田浩一
  • Organizer: 日本臨床分子学会
  • Place of Presentation: 大阪医科大学、大阪
  • Year and Date: 2011-09-09
• [Presentation] 上皮細胞の極性形成・維持におけるアダプター蛋白質ArgBP2の役割 (2011)
  • Author(s): 村瀬香奈
  • Organizer: 日本臨床分子形態学会
  • Place of Presentation: 大阪医科大学（大阪）
• [Presentation] 神経突起伸長におけるMAGI-1の機能解析 (2011)
  • Author(s): 伊東秀記
  • Organizer: 日本生化学会
  • Place of Presentation: 京都国際会館（京都）
• [Presentation] Functional analysis of Dysbindin, a schizophrenia risk factor, in dendritic spine formation. (2011)
  • Author(s): 永田浩一
  • Organizer: 米国細胞生物学会
  • Place of Presentation: コロラドコンベンションセンター（デンバー、米国）
• [Presentation] Dysbindin-1, a schizophrenia risk factor, regulates dendritic spine formation : Evidence supporting neurodevelopmenta1 hypothesis. (2010)
  • Author(s): 伊東秀記, 森下理香, 篠田友靖, 岩本郁子, 須藤香織, 岡本賢一, 永田浩一
  • Organizer: 米国細胞生物学会
  • Place of Presentation: ペンシルバニアコンペンションセンター、フィラデルフィア、米国
  • Year and Date: 2010-12-14
• [Presentation] Dysbindin-1, a schizophrenia risk factor, regulates dendritic spine formation : Evidence supporting neurodevelopmental hypothesis. (2010)
  • Author(s): 永田浩一
  • Organizer: 米国細胞生物学会
  • Place of Presentation: フィラデルフィア コンベンションセンター(フィラデルフィア)
  • Year and Date: 2010-12-14
• [Presentation] Molecular mechanism of Septin-mediated migration of cortical neurons. (2010)
  • Author(s): 篠田友靖, 伊東秀記, 須藤香織, 岩本郁子, 森下理香, 貝淵弘三, 永田浩一
  • Organizer: BMB2010
  • Place of Presentation: 神戸国際会議場、神戸
  • Year and Date: 2010-12-08
• [Presentation] Molecular mechanism of Septin-mediated migration of cortical neurons. (2010)
  • Author(s): 篠田友靖
  • Organizer: BMB2010
  • Place of Presentation: 神戸国際会議場(兵庫県)
  • Year and Date: 2010-12-08
• [Presentation] Biochemical and histological characterization of MAGI-1 in rat nervous tissues. (2010)
  • Author(s): 伊東秀記, 森下理香, 篠田友靖, 須藤香織, 岩本郁子, 永田浩一
  • Organizer: BMB2010
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2010-12-07
• [Presentation] Biochemical and histological characterization of MAGI-1 in rat nervoustissues. (2010)
  • Author(s): 伊東秀記
  • Organizer: BMB2010
  • Place of Presentation: 神戸国際会議場(兵庫県)
  • Year and Date: 2010-12-07
• [Presentation] Septinの大脳皮質形成における機能およびその分子メカニズム (2010)
  • Author(s): 篠田友靖, 伊東秀記, 須藤香織, 岩本郁子, 森下理香, 永田浩一
  • Organizer: Neuro2010
  • Place of Presentation: 神戸
  • Year and Date: 2010-09-03
• [Presentation] Septinの大脳皮質形成における機能およびその分子メカニズム (2010)
  • Author(s): 篠田友靖
  • Organizer: Neuro2010
  • Place of Presentation: 神戸国際会議場(兵庫県)
  • Year and Date: 2010-09-03
• [Presentation] Dysbindin-1はWAVE2/Abi-1複合体形成を介して神経細胞の樹状突起形態を制御する. (2010)
  • Author(s): 伊東秀記, 森下理香, 篠田友靖, 須藤香織, 岩本郁子, 永田浩一
  • Organizer: Neuro2010
  • Place of Presentation: 神戸
  • Year and Date: 2010-09-02
• [Presentation] Dysbindin-1はWAVE2/Abi-1複合体を介して神経細胞の樹状突起形態を制御する (2010)
  • Author(s): 伊東秀記
  • Organizer: Neuro2010
  • Place of Presentation: 神戸国際会議場(兵庫県)
  • Year and Date: 2010-09-02
• [Remarks] 愛知県心身障害者コロニー発達障害研究所
  • URL: http://www.inst-hsc.jp
• [Remarks] 愛知県心身障害者コロニー発達障害研究所
  • URL: http://www.inst-hsc.jp
• [Remarks] 愛知県心身障害者コロニー発達障害研究所
  • URL: http://www.inst-hsc.jp
• [Remarks]
  • URL: http://www.inst-hsc.jp