Grant-in-Aid for Scientific Research (C)
I found several results for new antimalarial drug development study against multi-drug resistant Plasmodium falciparum.1. A few numbers of compounds indicating the 1μM of antimalarial activity for P. falciparum (FCR-3 strain) were acquired using 40 kinds of organic synthetic compounds having peroxide structure in the body and 20 kinds of compounds from the natural product.2. To evaluate of antimalarial activity for N-89 in clinical model system of malaria patients, N-89 has high and strong antimalarial activity in more than 5% of parasitemia of P. bergheiinfected-mice model on oral route of it.3. I prepared several kinds of N-89 formula for long lasting effect in blood concentration of mice model. As results, the different formulation of N-89 has weak antimalarial activity compare of oil-N-89 but they did not changed pharmacokinetic parameters in mice compare of oil-N-89.
Research on Chemical Intermediate
J Proteome Res
Volume: 60 (4)
Volume: (in press)
Chemistry and Physics of Lipids
Biosci. Biotecgnol. Biochem.
Volume: 73 (1)
Volume: (In press)
Attribution of KAKENHI