| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Research Abstract |
A versatile method for the synthesis of DTPA bearing functionalized side chain was successfully accomplished. Introduction of only one side chain to DTPA, the key reaction, was succeeded in spite of the five reacting points in DTPA framework. Introduction of functional group at the terminus of the side chain, and connection of several pharmacokintic molecules with the functionalgroup was also succeeded. A parameter for MRI contrast of the target molecule was measured by MRI spectrometer. A compound was injected to mice to observe MRI image.
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