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Oxidative stress imaging in organelle by novel TEMPO derivatives

Research Project

Project/Area Number 22590103
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Drug development chemistry
Research InstitutionNagoya City University

Principal Investigator

NAKAGAWA Hidehiko  名古屋市立大学, 大学院・薬学研究科, 准教授 (80281674)

Co-Investigator(Renkei-kenkyūsha) MIYATA Naoki  名古屋市立大学, 大学院・薬学研究科, 教授 (50114674)
SUZUKI Takayoshi  名古屋市立大学, 大学院・薬学研究科, 講師 (90372838)
TSUMOTO Hiroki  名古屋市立大学, 大学院・薬学研究科, 特任助教 (00409385)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords生物活性物質 / 活性酸素種 / 薬学 / 有機化学 / ストレス / 分析科学 / 細胞・組織 / 酸化還元
Research Abstract

Chemical probes for measuring and imaging nuclei-specific oxidative stress have been synthesized. The probes were fluorescent and responsible to cellular oxidative stress, and one of them was applicable to in vivo-ESR imaging.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (17 results)

All 2012 2011 2010 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (10 results) (of which Invited: 1 results) Remarks (4 results)

  • [Journal Article] Novel bisbenzimide-nitroxides for nuclear redox imaging in living cells2012

    • Author(s)
      池田麻美子、中川秀彦, 他2名
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters

      Volume: 22 Issue: 5 Pages: 1949-1952

    • DOI

      10.1016/j.bmcl.2012.01.042

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of a DNA-binding TEMPO derivative for evaluation of nuclear oxidative stress and its application in living cells2010

    • Author(s)
      Mamiko Ikeda, Hidehiko Nakagawa, Shizuka Ban, Hiroki Tsumoto, Takayoshi Suzuki, and Naoki Miyata
    • Journal Title

      Free Radic. Biol. Med

      Volume: 49 Issue: 11 Pages: 1792-1797

    • DOI

      10.1016/j.freeradbiomed.2010.09.009

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of a DNA-binding TEMPO derivative for evaluation of nuclear oxidative stress and its application in living cells2010

    • Author(s)
      Mamiko Ikeda, et al
    • Journal Title

      Free Radic.Biol.Med.

      Volume: 49 Pages: 1792-1797

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] オルガネラ局在性TEMPO スピンプローブによる核内の酸化ストレス計測2012

    • Author(s)
      中川秀彦
    • Organizer
      第51回電子スピンサイエンス学会年会
    • Place of Presentation
      札幌
    • Year and Date
      2012-11-03
    • Related Report
      2012 Final Research Report
  • [Presentation] 環境酸化ストレスの細胞影響評価を志向したニトロキシド-蛍光プローブ2012

    • Author(s)
      中川秀彦
    • Organizer
      フォーラム2012衛生薬学・環境トキシコロジー
    • Place of Presentation
      名古屋
    • Year and Date
      2012-10-25
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] オルガネラ局在性TEMPOスピンプローブによる核内の酸化ストレス計測2012

    • Author(s)
      中川秀彦
    • Organizer
      第51回電子スピンサイエンス学会年会
    • Place of Presentation
      札幌
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Diverse oxidative stress in a living cell probed by organelle-specific TEMPO derivatives2011

    • Author(s)
      Hidehiko Nakagawa, et al.
    • Organizer
      AEBST2011
    • Place of Presentation
      神戸
    • Year and Date
      2011-11-13
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] 核局在性を有する新規 fluorophore-nitroxide プローブの開発2011

    • Author(s)
      池田麻美子, 中川秀彦
    • Organizer
      第64回日本酸化ストレス学会学術集会
    • Place of Presentation
      ルスツ(北海道)
    • Year and Date
      2011-07-02
    • Related Report
      2012 Final Research Report
  • [Presentation] 核局在性を有する新規fluorophore-nitroxideプローブの開発2011

    • Author(s)
      池田麻美子, ほか
    • Organizer
      第64回日本酸化ストレス学会学術集会
    • Place of Presentation
      ルスツ(北海道)
    • Year and Date
      2011-07-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] 細胞内一重項酸素検出を目指したミトコンドリア分布型TMP誘導体の合成と評価2011

    • Author(s)
      田中裕子, ほか
    • Organizer
      第64回日本酸化ストレス学会学術集会
    • Place of Presentation
      ルスツ(北海道)
    • Year and Date
      2011-07-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] 細胞内部位特異的酸化ストレス評価を目指したオルガネラ分布型スピンプ ローブの開発2011

    • Author(s)
      池田麻美子, 中川秀彦
    • Organizer
      第9回次世代を担う有機化学シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2011-05-27
    • Related Report
      2012 Final Research Report
  • [Presentation] 細胞内部位特異的酸化ストレス評価を目指したオルガネラ分布型スピンプローブの開発2011

    • Author(s)
      池田麻美子, ほか
    • Organizer
      第9回次世代を担う有機化学シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2011-05-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] Organelle-specific evaluation of nuclear redox status with a DNA binding spin probe2010

    • Author(s)
      Mamiko Ikeda, Hidehiko Nakagawa, et al.
    • Organizer
      Pacifichem2010
    • Place of Presentation
      Honolulu, HI, U.S.A.
    • Year and Date
      2010-12-19
    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Remarks] アウトリーチ活動(研究成果公開・解説)

    • URL

      http://www.nagoya-cu.ac.jp/phar/1046.htm

    • Related Report
      2012 Final Research Report
  • [Remarks] 名古屋市立大学大学院薬学研究科・薬学部(薬化学分野)

    • URL

      http://www.nagoya-cu.ac.jp/phar/1046.htm

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.phar.nagoya-cu.ac.jp/research_course/res_course01.html

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.phar.nagoya-cu.ac.jp/research_course/res_course01.html

    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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