Oxidative stress imaging in organelle by novel TEMPO derivatives
| Project/Area Number |
22590103
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Drug development chemistry
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| Research Institution | Nagoya City University |
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Principal Investigator |
NAKAGAWA Hidehiko 名古屋市立大学, 大学院・薬学研究科, 准教授 (80281674)
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| Co-Investigator(Renkei-kenkyūsha) |
MIYATA Naoki 名古屋市立大学, 大学院・薬学研究科, 教授 (50114674)
SUZUKI Takayoshi 名古屋市立大学, 大学院・薬学研究科, 講師 (90372838)
TSUMOTO Hiroki 名古屋市立大学, 大学院・薬学研究科, 特任助教 (00409385)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 生物活性物質 / 活性酸素種 / 薬学 / 有機化学 / ストレス / 分析科学 / 細胞・組織 / 酸化還元 |
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| Research Abstract |
Chemical probes for measuring and imaging nuclei-specific oxidative stress have been synthesized. The probes were fluorescent and responsible to cellular oxidative stress, and one of them was applicable to in vivo-ESR imaging.
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Report
(4 results)
Research Products
(17 results)
