Creation of novel anticancer lead compounds by in silico design of XIAP antagonists
Project/Area Number |
22590107
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Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Drug development chemistry
|
Research Institution | Tokyo University of Science |
Principal Investigator |
TAMURA Seiichi 東京理科大学, 薬学部薬学科, 教授 (10142449)
|
Co-Investigator(Kenkyū-buntansha) |
TAKASAWA Ryoko 東京理科大学, 薬学部・薬学科, 講師 (10398828)
|
Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 医薬分子設計 / 癌 / シグナル伝達 / 薬学 |
Research Abstract |
XIAP, which is involved in resistances for anticancer drugs and irradiation, is an attractive target for the development of new anticancer drugs. In this study, we attempted to create novel lead compounds for new anticancer drugs. As a result, we could discover a novel agonistic compound, which possess a good binding form to XIAP.
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Report
(4 results)
Research Products
(46 results)
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[Journal Article] A new protocol to discover novel anti-aging compounds2012
Author(s)
F. Uchiumi, T. Oyama, K. Ozaki, M. Fukui, H. Ogawa, Y. Sasaki, H. Tachibana, C. Fukushima, M. Fujikawa, H. Abe, S. Larsen, S. Tanuma
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Journal Title
Pharmaceutica Analytica Acta
Volume: 3
Issue: 07
Pages: 166-166
DOI
Related Report
Peer Reviewed
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[Journal Article] Structural insights into the hot spot amino acid residues of mushroom tyrosinase for the bindings of thujaplicins.2010
Author(s)
Takahashi S, Kamiya T, Saeki K, Nezu T, Takeuchi S, Takasawa R, Sunaga S, Yoshimori A, Ebizuka S, Abe T, Tanuma S.
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Journal Title
Bioorg Med Chem.
Volume: VOL.18
Pages: 8112-8118
Related Report
Peer Reviewed
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