Development of membrane-permeable Aib-containing peptide for delivery of oligonucleotide drugs
| Project/Area Number |
22590109
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Drug development chemistry
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| Research Institution | Osaka University of Pharmaceutical Sciences |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
URATA Hidehito 大阪薬科大学, 薬学部, 教授 (80211085)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | Aib / 膜透過性ペプチド / ヘリックス / 核酸医薬 / アンチセンス / 核酸医薬品 |
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| Research Abstract |
Oligonucleotide (ODN) drugs have interesting therapeuticpotentials in various biological applications. However, charged polar ODNs typicallyexhibit poor membrane permeabilization. My designed Aib-containing peptides showmembrane permeable properties, and have the potential for delivery of ODNs into cells.
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Report
(4 results)
Research Products
(16 results)
