Restructure and structure-activity relationship of the osteoporotic improvement effect compounds derived from echinoderms.
| Project/Area Number |
22590112
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Drug development chemistry
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| Research Institution | Yasuda Women's University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MORIMOTO Chie 松山東雲短期大学, 生活科学科, 准教授 (10332826)
TAKEDA Yoshio 安田女子大学, 薬学部, 教授 (70025716)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 生体分子 / 生理活性 / 骨粗鬆症 / 棘皮動物 |
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| Research Abstract |
In the study of the constituents of echinoderms, we found that the echinoderms such as starfish had the glycosphingolipids (GSLs) which improvedosteoporosis. However, we did not know it in detail what kind of partial structure was necessary. This time, we obtained GSLs from Acanthaster planci and the compounds whichwere provided by rebuilding it chemically again. The partial structure, necessary for active expression, was suggested by cell-based assay.
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Report
(4 results)
Research Products
(3 results)
