Study for protective and harmful effects of environmental factors on emotional system and its development

• Project/Area Number: 22590118
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Environmental pharmacy
• Research Institution: Kumamoto University
• Principal Investigator: SHIRASAKI Tetsuya 熊本大学, 大学院・生命科学研究部, 准教授 (30264047)
• Co-Investigator(Kenkyū-buntansha): TAKAHAMA Kazuo 熊本大学, 大学院・生命科学研究部, 教授 (80150548) ; SOEDA Fumio 熊本大学, 大学院・生命科学研究部, 助教 (10336216)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 環境衛生学 / 神経発達 / 生後早期ストレス / 情動機能障害 / 自然環境音 / 疾病予防 / 母仔隔離 / 白色雑音刺激 / モノアミン / GIRKチャネル / 腹側被蓋 / 海馬CA1 / パッチクランプ / 行動科学試験 / 環境 / 衛生薬学 / 神経科学 / ストレス / 生理学

Research Abstract

We studied how environmental factors in early life stage affectemotional brain functions by using electrophysiological, neurochemical and behavioralscience techniques. Psychologically stressful environments alter receptor functions tomonoamines and/or amino acids or responsiveness to them. Expression levels of GIRK2 and5-HT1Areceptor were not affected. Short but repeated maternal isolation tended to increaseaggressive behavior. Environmental natural sounds such as sounds of a stream protectedfrom the effects observed at single neuron level of short but repeated maternal isolation.

Research Products

• [Presentation] Effectsof early life stress on ionic currentsin the CNS neurons and neuro-behaviorsand its attenuation by natural sounds (2012)
  • Author(s): Tetsuya Shirasaki, Ryota Hamasaki,Fumio Soeda, Kazuo Takahama
  • Organizer: Neuroscience 2012
  • Place of Presentation: NewOrleans USA Ernest N. MorialConvention Center
• [Presentation] Effects of early life stress on ionic currents in the CNS neurons and behavior and amelioration by exposure to natural sounds. (2012)
  • Author(s): Tetsuya Shirasaki, Ryota Hamasaki, Fumio Soeda, Kazuo Takahama.
  • Organizer: Neuroscience 2012
  • Place of Presentation: New Orleans, USA
• [Presentation] Maternal isolation affects function of GIRK channels in neurons of the hippocampus but not the raphe nucleus. (2010)
  • Author(s): 白崎哲哉
  • Organizer: Neuroscience 2010
  • Place of Presentation: 米国 サンディエゴコンベンションセンター
  • Year and Date: 2010-11-15
• [Presentation] Maternal isolation affects function ofGIRK channels in neurons of thehippocampus but not the raphe nucleus (2010)
  • Author(s): Tetsuya Shirasaki, Ahmed M.Shehata, Fumio Soeda, Kazuo Takahama
  • Organizer: Neuroscience 2010
  • Place of Presentation: SanDiego USA San Diego Convention Center