| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
Serum fee fatty acid, especially palmitic acid (PA) is shown to induce endoplasmic reticulum stress marker expression, both in MacA RH7777 cells, and rats in vivo, while the effects of oleic acid, palmitoleic acid and cis-vaccenic acid were faint compared to PA. The induction of ER stress in liver induced by PA in vivo was protected by pretreatment of cofibric acid. The results suggested that hepatic ER stress is protected by reducing the levels of free fatty acid, especially palmitic acid
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