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Phase Control of Circadian Rhythms by Heme as a Key Molecule

Research Project

Project/Area Number 22590121
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Environmental pharmacy
Research InstitutionJosai International University

Principal Investigator

MITSUMOTO Atsushi  城西国際大学, 薬学部, 教授 (00276164)

Co-Investigator(Renkei-kenkyūsha) KAWAI Hiroshi  城西国際大学, 薬学部, 講師(現准教授) (20321854)
ISHIBASHI Takuya  城西国際大学, 薬学部, 助手 (20555825)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Keywords中毒学 / 概日リズム / 生物時計 / 化学物質中毒 / ヘム / ポルフィリン症 / グリセオフルビン / 疾病モデル動物 / 位相
Research Abstract

We have investigated the role of heme as a key molecule to control the phase of circadian rhythms in mice, using griseofulvin-induced porphyria model. Our research product has recently been published in Am J Physiol. Moreover, we advanced the research project based on the difference of drug sensitivity of the mice, we have established the model mice of alcohol dependence, and found that some substances could work as therapeutic and preventive drug for the disease.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (49 results)

All 2013 2012 2011 2010 Other

All Journal Article (23 results) (of which Peer Reviewed: 11 results) Presentation (25 results) Remarks (1 results)

  • [Journal Article] Up-Regulation of Stearoyl-CoA Desaturase 1 Increases Liver MUFA Content in Obese Zucker but Not Goto-Kakizaki Rats2013

    • Author(s)
      Karahashi M, Ishii F, Yamazaki T, Imai K, Mitsumoto A, Kawashima Y, Kudo N
    • Journal Title

      Lipids

      Pages: 457-67

    • NAID

      120005520870

    • Related Report
      2012 Final Research Report
  • [Journal Article] An example of self-evaluation of a sense of achievement by students in 6-year pharmacy school with the model core curriculum of pharmaceutical education2013

    • Author(s)
      Shingaki T, Koyanagi J, Nakamura H, Hirata T, Ohta A, Akimoto M, Shirahata A, Mitsumoto A.
    • Journal Title

      Yakugaku Zasshi

      Volume: 133 Pages: 141-8

    • NAID

      130001888737

    • Related Report
      2012 Final Research Report
  • [Journal Article] Up-Regulation of Stearoyl-CoA Desaturase 1 Increases Liver MUFA Content in Obese Zucker but Not Goto-Kakizaki Rats.2013

    • Author(s)
      Karahashi M, Ishii F, Yamazaki T, Imai K, Mitsumoto A, Kawashima Y, Kudo N.
    • Journal Title

      Lipids

      Volume: 48 Issue: 5 Pages: 457-67

    • DOI

      10.1007/s11745-013-3786-2

    • NAID

      120005520870

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] [An example of self-evaluation of a sense of achievement by students in 6-year pharmacy school with the model core curriculum of pharmaceutical education].2013

    • Author(s)
      Shingaki T, Koyanagi J, Nakamura H, Hirata T, Ohta A, Akimoto M, Shirahata A, Mitsumoto A.
    • Journal Title

      Yakugaku Zasshi

      Volume: 133 Pages: 141-8

    • NAID

      130001888737

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Behavioral and biochemical characterization of rats treated chronically with thioacetamide: proposal of an animal model for hepatic encephalopathy associated with cirrhosis2012

    • Author(s)
      Kawai H, Ishibashi T, Kudo N, Kawashima Y, Mitsumoto A.
    • Journal Title

      J Toxicol Sci

      Volume: 37 Pages: 1165-75

    • NAID

      10031126021

    • Related Report
      2012 Final Research Report
  • [Journal Article] Induction of 1-acylglycerophosphocholine acyltransferase genes by fibrates in the liver of rats2012

    • Author(s)
      Yamazaki T, Wakabayashi M, Ikeda E, Tanaka S, Sakamoto T, Mitsumoto A, Kudo N, Kawashima Y.
    • Journal Title

      Biol Pharm Bull.

      Volume: 35 Pages: 1509-15

    • NAID

      130001872074

    • Related Report
      2012 Final Research Report
  • [Journal Article] Impairment of heme biosynthesis induces short circadian period in body temperature rhythms in mice2012

    • Author(s)
      Iwadate R, Satoh Y, Watanabe Y, Kawai H, Kudo N, Kawashima Y, Mashino T, Mitsumoto A.
    • Journal Title

      Am J Physiol Regul Integr Comp Physiol

      Volume: 303

    • Related Report
      2012 Final Research Report
  • [Journal Article] Characterization of fatty acid profile in the liver of SHR/NDmcr-cp (cp/cp) rats, a model of the metabolic syndrome.2012

    • Author(s)
      Tanaka S, Yagi Y, Yamazaki T, Mitsumoto A, Kobayashi D, Kudo N, Kawashima Y.
    • Journal Title

      Biol Pharm Bull.

      Volume: 35 Pages: 184-191

    • NAID

      130001872292

    • Related Report
      2012 Final Research Report
  • [Journal Article] Differential induction of stearoyl-CoA desaturase 1 and 2 genes by fibrates in the liver of rats2012

    • Author(s)
      Yamazaki T, Okada H, Sakamoto T, Sunaga K, Tsuda T, Mitsumoto A, Kudo N, Kawashima Y.
    • Journal Title

      Biol Pharm Bull

      Volume: 35 Pages: 116-120

    • NAID

      130001872334

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Journal Article] Behavioral and biochemical characterization of rats treated chronically with thioacetamide: proposal of an animal model for hepatic encephalopathy associated with cirrhosis.2012

    • Author(s)
      Kawai H, Ishibashi T, Kudo N, Kawashima Y, Mitsumoto A.
    • Journal Title

      J Toxicol Sci.

      Volume: 37 Pages: 1165-75

    • NAID

      10031126021

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Induction of 1-acylglycerophosphocholine acyltransferase genes by fibrates in the liver of rats.2012

    • Author(s)
      Yamazaki T, Wakabayashi M, Ikeda E, Tanaka S, Sakamoto T, Mitsumoto A, Kudo N, Kawashima Y.
    • Journal Title

      Biol Pharm Bull.

      Volume: 35 Pages: 1509-15

    • NAID

      130001872074

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impairment of heme biosynthesis induces short circadian period in body temperature rhythms in mice.2012

    • Author(s)
      Iwadate R, Satoh Y, Watanabe Y, Kawai H, Kudo N, Kawashima Y, Mashino T, Mitsumoto A.
    • Journal Title

      Am J Physiol Regul Integr Comp Physiol.

      Volume: 303 Issue: 1 Pages: R8-R18

    • DOI

      10.1152/ajpregu.00019.2011

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impairment of Heme Biosynthesis Induces Short Circadian Period in Body Temperature Rhythms in Mice2012

    • Author(s)
      Iwadate R, Satoh Y, Watanabe Y, Kawai H, Kudo N, Kawashima Y, Mashino T, Mitsumoto A
    • Journal Title

      Am J Physiol Regul Integr Comp Physiol

      Volume: (未定)(Accepted)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of fatty acid profile in the liver of SHR/NDmcr-cp (cp/cp) rats, a model of the metabolic syndrome2012

    • Author(s)
      Tanaka S, Yagi Y, Yamazaki T, Mitsumoto A, Kobayashi D, Kudo N, Kawashima Y
    • Journal Title

      Biol Pharm Bull

      Volume: 35 Pages: 184-191

    • NAID

      130001872292

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clofibric acid increases the formation of oleic acid in endoplasmic reticulum of the liver of rats2011

    • Author(s)
      Hirose A, Yamazaki T, Sakamoto T, Sunaga K, Tsuda T, Mitsumoto A, Kudo N, Kawashima Y
    • Journal Title

      J Pharmacol Sci.

      Volume: 116 Pages: 362-372

    • NAID

      10029895608

    • Related Report
      2012 Final Research Report
  • [Journal Article] Effects of perfluorinated fatty acids with different carbon chain length on fatty acid profiles of hepatic lipids in mice.2011

    • Author(s)
      Kudo N, Yamazaki T, Sakamoto T, Sunaga K, Tsuda T, Mitsumoto A, Kawashima Y
    • Journal Title

      Biol Pharm Bull

      Volume: 34 Pages: 856-864

    • NAID

      130000738061

    • Related Report
      2012 Final Research Report
  • [Journal Article] 薬剤師による臨床診断 -レッドフラッグシステムによるトリアージ-2011

    • Author(s)
      佐仲雅樹, 光本篤史, 徳田安春
    • Journal Title

      Clinical Pharmacist

      Volume: 3 Pages: 492-496

    • NAID

      40018983827

    • Related Report
      2012 Final Research Report
  • [Journal Article] Clofibric acid increases the formation of oleic acid in endoplasmic reticulum of the liver of rats2011

    • Author(s)
      Hirose A, Yamazaki T, Sakamoto T, Sunaga K, Tsuda T, Mitsumoto A, Kudo N, Kawashima Y
    • Journal Title

      J Pharmacol Sci

      Volume: 116 Pages: 362-372

    • NAID

      10029895608

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of perfluorinated fatty acids with different carbon chain length on fatty acid profiles of hepatic lipids in mice2011

    • Author(s)
      Kudo N, Yamazaki T, Sakamoto T, Sunaga K, Tsuda T, Mitsumoto A, Kawashima Y
    • Journal Title

      Biol Pharm Bull

      Volume: 34 Pages: 856-864

    • NAID

      130000738061

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 薬剤師による臨床診断-レッドフラッグシステムによるトリアージ-2011

    • Author(s)
      佐仲雅樹、光本篤史、徳田安春
    • Journal Title

      Clinical Pharmacist

      Volume: 3 Pages: 492-496

    • NAID

      40018983827

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Effects of perfluorinated fatty acids with different carb on chain length on fatty acid profiles of hepatic lipids in mice2011

    • Author(s)
      Naomi Kudo, Tohru Yamazaki, Takeshi Sakamoto, Katsuyoshi Sunaga, Tadashi Tsuda, Atsushi Mitsumoto, Yoichi Kawashiama
    • Journal Title

      Biol Pharm Bull.

      Volume: Vol.34(Accepted)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 就寝前の牛乳摂取が睡眠の質に及ぼす影響2010

    • Author(s)
      渡邉ゆきの, 佐藤陽子, 河合洋, 光本篤史
    • Journal Title

      Food Function

      Volume: 6 Pages: 21-29

    • NAID

      40020152083

    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Journal Article] Differential response of hepatic porphyria mice to diazepam.2010

    • Author(s)
      Watanabe Y, Kawai H, Kudo N, Kawashima Y, Mitsumoto A.
    • Journal Title

      Porphyrins

      Volume: Vol.18(Accepted)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Chronopharmacological analysis of antidepressant activity of serotonin-noradrenaline reuptake inhibitor (SNRI),milnacipran2013

    • Author(s)
      Hiroshi Kawai, Megumi Machida, Ayano Igari, Takuya Ishibashi, Atsushi Mitsumoto
    • Organizer
      日本薬理学会
    • Place of Presentation
      博多
    • Related Report
      2012 Final Research Report
  • [Presentation] アルコール依存症離脱時における不安発症メカニズムの解析2013

    • Author(s)
      長島航平, 土屋勇太, 久保田祥, 高橋翔平, 植田久美子, 石橋拓也, 河合洋, 光本篤史
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] うつ病態モデルマウスの概日リズムの解析2013

    • Author(s)
      猪狩文乃, 鈴木文子, 河合洋, 石橋拓也, 光本篤史
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] 尿中物質を用いたヒト肝臓リズムの新規評価法2013

    • Author(s)
      富樫優太郎, 河合洋, 石橋拓也, 光本篤史
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] 6年制薬学生のヒューマニズム教育による意識変容2013

    • Author(s)
      小柳順一, 中村洋, 亀井美子, 新垣知輝, 秋元雅之, 光本篤史
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] Chronopharmacological analysis of antidepressant activity of serotonin-noradrenaline reuptake inhibitor (SNRI), milnacipran.2013

    • Author(s)
      ○Hiroshi Kawai, Megumi Machida, Ayano Igari, Takuya Ishibashi, Atsushi Mitsumoto
    • Organizer
      日本薬理学会
    • Place of Presentation
      博多
    • Related Report
      2012 Annual Research Report
  • [Presentation] 6年制薬学生のヒューマニズム教育による意識変容2013

    • Author(s)
      ○小柳順一、中村洋、亀井美子、新垣知輝、秋元雅之、光本篤史
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
  • [Presentation] アルコール依存症の離脱症状発現に関わる因子の解析2012

    • Author(s)
      石橋拓也, 奥原千尋, 久保田祥, 藤原寛太, 長島航平, 土屋勇太, 金森穂高, 田口徹, 河合洋, 光本篤史
    • Organizer
      日本薬学会第132 年会
    • Place of Presentation
      札幌
    • Related Report
      2012 Final Research Report
  • [Presentation] 健常成人の睡眠測定におけるマット型睡眠計の有用性の検討2012

    • Author(s)
      河合洋, 富樫優太郎, 石橋拓也, 光本篤史
    • Organizer
      日本薬学会第132 年会
    • Place of Presentation
      札幌
    • Related Report
      2012 Final Research Report
  • [Presentation] 薬局訪問にエイジ・ミキシング法を取り入れた試み22012

    • Author(s)
      二村典行, 奥山恵美, 高橋たみ子, 小柳順一, 長谷川哲也, 小嶋文良, 光本篤史
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] 城西国際大学における実務実習後のアドバンス教育(その1) -薬学特別演習の開講-2012

    • Author(s)
      中村洋, 渡辺大輔, 扶川武志, 新垣知輝, 高橋たみ子, 光本篤史
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌
    • Related Report
      2012 Final Research Report
  • [Presentation] 城西国際大学における実務実習後のアドバンス教育(その2) -薬学特別演習におけるポートフォリオの活用-2012

    • Author(s)
      中村洋, 渡辺大輔, 扶川武志, 新垣知輝, 高橋たみ子, 光本篤史
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌
    • Related Report
      2012 Final Research Report
  • [Presentation] アルコール依存症の離脱症状発現に関わる因子の解析2012

    • Author(s)
      石橋拓也、奥原千尋、久保田祥、藤原寛太、長島航平、土屋勇太、金森穂高、田口徹、河合洋、光本篤史
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌
    • Related Report
      2011 Annual Research Report
  • [Presentation] 健常成人の睡眠測定におけるマット型睡眠計の有用性の検討2012

    • Author(s)
      河合洋、富樫優太郎、石橋拓也、光本篤史
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌
    • Related Report
      2011 Annual Research Report
  • [Presentation] 城西国際大学における実務実習後のアドバンス教育(その1)-薬学特別演習の開講-2012

    • Author(s)
      中村洋、渡辺大輔、扶川武志、新垣知輝、高橋たみ子、光本篤史
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌
    • Related Report
      2011 Annual Research Report
  • [Presentation] 城西国際大学における実務実習後のアドバンス教育(その2)-薬学特別演習におけるポートフォリオの活用-2012

    • Author(s)
      中村洋、渡辺大輔、扶川武志、新垣知輝、高橋たみ子、光本篤史
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌
    • Related Report
      2011 Annual Research Report
  • [Presentation] 薬局訪問にエイジ・ミキシング法を取り入れた試み2011

    • Author(s)
      小柳順一、高橋たみ子、奥山恵美、長谷川哲也、小嶋文良、光本篤史
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      静岡(静岡県立大)
    • Year and Date
      2011-03-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] アクチグラフィーとマット型睡眠計による睡眠指標の相関解析2011

    • Author(s)
      河合洋, 石橋拓也, 飯村可南子, 土井正人, 中村裕次, 西春香, 田中伸幸, 富樫優太郎, 光本篤史
    • Organizer
      日本睡眠学会第36回定期学術集会
    • Place of Presentation
      京都
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] 薬局訪問にエイジ・ミキシング法を取り入れた試み2011

    • Author(s)
      小柳順一, 高橋たみ子, 奥山恵美, 長谷川哲也,小嶋文良, 光本篤史
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      静岡
    • Related Report
      2012 Final Research Report
  • [Presentation] 動物実験代替法を取入れた薬学部の学内実習2010

    • Author(s)
      長谷川哲也、河合洋、松本かおり、石橋拓也、松本健次郎、田嶋公人、光本篤史、児玉庸夫、堀江俊治、秋元雅之
    • Organizer
      日本動物実験代替法学会第23回大会
    • Place of Presentation
      東京(北里大学)
    • Year and Date
      2010-12-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] 大網病院における医薬品に関する情報提供の実態調査2010

    • Author(s)
      森恒雄、齊藤佳子、光本篤史、小嶋文良
    • Organizer
      第59回千葉県国民健康保険直営診療施設医療学会
    • Place of Presentation
      千葉(オークラ千葉ホテル)
    • Year and Date
      2010-11-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] ヘム代謝異常マウスは短周期の概日リズムを示す2010

    • Author(s)
      岩舘怜子、佐藤陽子、河合洋、増野匡彦、光本篤史
    • Organizer
      第17回日本時間生物学会
    • Place of Presentation
      東京(早稲田大学)
    • Year and Date
      2010-11-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] ヘム代謝異常マウスは短周期の概日リズムを示す2010

    • Author(s)
      岩舘怜子, 佐藤陽子, 河合洋, 増野匡彦, 光本篤史
    • Organizer
      第17回日本時間生物学会
    • Place of Presentation
      東京早稲田
    • Related Report
      2012 Final Research Report
  • [Presentation] 大網病院における医薬品に関する情報提供の実態調査2010

    • Author(s)
      森恒雄, 齊藤佳子, 光本篤史, 小嶋文良
    • Organizer
      第59回千葉県国民健康保険直営診療施設医療学会
    • Place of Presentation
      千葉
    • Related Report
      2012 Final Research Report
  • [Presentation] 動物実験代替法を取入れた薬学部の学内実習2010

    • Author(s)
      長谷川哲也, 河合洋, 松本かおり, 石橋拓也, 松本健次郎, 田嶋公人, 光本篤史, 児玉庸夫, 堀江俊治, 秋元雅之
    • Organizer
      日本動物実験代替法学会第23回大会
    • Place of Presentation
      東京北里
    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://www.jiu.ac.jp/faculty/pc/eisei.html

    • Related Report
      2012 Final Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

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