Phase Control of Circadian Rhythms by Heme as a Key Molecule
| Project/Area Number |
22590121
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental pharmacy
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| Research Institution | Josai International University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
KAWAI Hiroshi 城西国際大学, 薬学部, 講師(現准教授) (20321854)
ISHIBASHI Takuya 城西国際大学, 薬学部, 助手 (20555825)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
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| Keywords | 中毒学 / 概日リズム / 生物時計 / 化学物質中毒 / ヘム / ポルフィリン症 / グリセオフルビン / 疾病モデル動物 / 位相 |
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| Research Abstract |
We have investigated the role of heme as a key molecule to control the phase of circadian rhythms in mice, using griseofulvin-induced porphyria model. Our research product has recently been published in Am J Physiol. Moreover, we advanced the research project based on the difference of drug sensitivity of the mice, we have established the model mice of alcohol dependence, and found that some substances could work as therapeutic and preventive drug for the disease.
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Report
(4 results)
Research Products
(49 results)
