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Assessment of motivational effects of psychiatric agents using rat intracranial self-stimulation behavior

Research Project

Project/Area Number 22590135
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Medical pharmacy
Research InstitutionOkayama University

Principal Investigator

SENDO Toshiaki  岡山大学, 岡山大学病院, 教授 (30437561)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords脳内自己刺激行動 / 強制水泳試験 / 条件づけ場所嗜好行動 / ドーパミン / 意欲 / GBR12909 / 動機づけ / SKF38393 / quinpirole / 条件付け場所嗜好行動
Research Abstract

In the present study, we evaluated the motivational effects of drugs using the novel experimental apparatus in order to accumulate the basal data for elucidating the basal data of neural mechanisms of motivation. The results revealed that dopamine, which was used for neurotransmission in the brain and involved in mood and rewards, played an important role. Furthermore, when the effects in the novel motivational model were compared with that of experimental models related to depressed mood and drug dependence, it was showed the possibility that different neural mechanisms are involved in depression, drug dependence and motivation.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (11 results)

All 2013 2011 2010

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (9 results)

  • [Journal Article] Effect of GBR12909 on affective behavior: Distinguishing motivational behavior from antidepressant-like and addiction-like behavior using the runway model of intracranial self-stimulation2013

    • Author(s)
      Esumi S, Sagara H, Nakamoto A, Kawasaki Y, Gomita Y, Sendo T
    • Journal Title

      Behavioural Brain Research

      Volume: 243 Pages: 313-21

    • NAID

      120005311980

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of GBR12909 on affective behavior: distinguishing motivational behavior from antidepressant-like and addiction-like behavior using the runway model of intracranial self-stimulation.2013

    • Author(s)
      Satoru Esumi
    • Journal Title

      Behavioural Brain Research

      Volume: 243 Pages: 313-21

    • DOI

      10.1016/j.bbr.2012.10.051

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] 脳内自己刺激行動のRunway法を用いた動機付け評価における各種抗うつ薬の影響2011

    • Author(s)
      江角悟、中本秋彦、河崎陽一、松永尚、千堂年昭
    • Organizer
      第39回薬物活性シンポジウム
    • Place of Presentation
      福岡県
    • Year and Date
      2011-11-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] Difference in the ef fect of Imipramine and GBR12909 on the Runway method using priming stimulation effect (PSE) of the intracranial self-stimulation (ICSS) behavior2011

    • Author(s)
      江角悟、河崎陽一、相良英憲、北村佳久、松永尚、五味田裕、千堂年昭
    • Organizer
      第21回日本臨床精神神経薬理学会・第41回日本神経精神薬理学会合同年会
    • Place of Presentation
      東京都
    • Year and Date
      2011-10-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] 脳内自己刺激行動のRunway法を用いた意欲および動機づけに作用する薬物の薬効評価系実験モデルの構築に関する検討2011

    • Author(s)
      江角悟、中本秋彦、河崎陽一、松永尚、千堂年昭
    • Organizer
      第22回霧島神経薬理フォーラム
    • Place of Presentation
      岡山県
    • Year and Date
      2011-08-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] 脳内自己刺激行動の Runway 法を用いた意欲および動機づけに作用する薬物の薬効評価系実験モデルの構築に関する検討2011

    • Author(s)
      江角 悟, 中本秋彦, 河崎陽一, 松永 尚, 千堂年昭
    • Organizer
      創薬・薬理フォーラム
    • Place of Presentation
      広島
    • Year and Date
      2011-08-06
    • Related Report
      2012 Final Research Report
  • [Presentation] 脳内自己刺激行動のRunway法を用いた意欲および動機づけに作用する薬物の薬効評価系実験モデルの構築に関する検討2011

    • Author(s)
      江角悟、中本秋彦、河崎陽一、松永尚、千堂年昭
    • Organizer
      創薬薬理フォーラム岡山
    • Place of Presentation
      広島県
    • Year and Date
      2011-08-06
    • Related Report
      2011 Annual Research Report
  • [Presentation] Influence of dopamine systems on the effect of GBR12909 in the runway method using intracranial self-stimulation behavior2011

    • Author(s)
      江角悟、河崎陽一、相良英憲、松永尚、五味田裕、千堂年昭
    • Organizer
      第84回日本薬理学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2011-03-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] Difference in the effect of Imipramine and GBR12909 on the and the Runway method using priming stimulation effect (PSE) of the intracranial self-stimulation (ICSS) behavior.2011

    • Author(s)
      江角 悟, 河崎陽一, 相良英憲, 北村佳久, 松永 尚, 五味田 裕, 千堂年昭
    • Organizer
      第21回臨床精神薬理学会・第41回日本神経精神薬理学会合同年会
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] 脳内自己刺激行動の Runway 法を用いた意欲および動機づけに作用する薬物の薬効評価系実験モデルの構築に関する検討2011

    • Author(s)
      江角 悟, 中本秋彦, 河崎陽一, 松永 尚, 千堂年昭
    • Organizer
      第22回霧島神経薬理フォーラム
    • Place of Presentation
      岡山
    • Related Report
      2012 Final Research Report
  • [Presentation] 脳内自己刺激行動のRunway法におけるPriming刺激効果に対するドパミン取込み阻害剤GBR12909の影響2010

    • Author(s)
      江角悟、河崎陽一、相良英憲、松永尚、五味田裕、千堂年昭
    • Organizer
      第49回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
    • Place of Presentation
      米子コンベンションセンター
    • Year and Date
      2010-11-06
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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