Construction of clinical usable prediction formula for removal rate by hemodialysis
Project/Area Number |
22590136
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Medical pharmacy
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Research Institution | Kumamoto University |
Principal Investigator |
HIRATA SUMIO 熊本大学, 薬学部, 教授 (10432999)
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Co-Investigator(Kenkyū-buntansha) |
KADOWAKI Daisuke 熊本大学, 薬学部, 准教授 (70433000)
西 一彦 熊本大学, 医学部附属病院, 准教授 (30264287)
竹澤 真吾 九州保健福祉大学, 保健科学部, 教授 (30171630)
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Project Period (FY) |
2010-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
Keywords | 薬物の透析性 / 透析膜 / 吸着 / 透析ラットモデル / 分布容積 / タンパク結合率 / 薬物吸着 / 超小型透析器 / 血液透析 / 透析による薬物除 / 透析膜への薬物吸着 / アミノグリコシド系抗菌 / AN69膜 / 透析除去率予測式 / 透析による薬物除去 |
Outline of Final Research Achievements |
“Removal of doripenem during hemodialysis and the optimum dosing regimen for patients undergoing hemodialysis” was published by Therapeutic Apheresis and Dialysis. Clinical and basic research of adsorption of arbekacin onto dialysis membranes is submitting to English journal. The investigation of dialyzability of drugs using anuric rat model has been in progress. Hemodialysis without anesthesia could be carried out, and dialysate and substitution fluid was changed from lactate ringer solution to SubloodB in a physical way. The dialyzability of vancomycin in anuric rat model was almost same as the dialyzability in patients.
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Report
(6 results)
Research Products
(114 results)
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[Journal Article] Direct Radical Scavenging Activity of Benzbromarone Provides Beneficial Antioxidant Properties for Hyperuricemia Treatment2015
Author(s)
Kadowaki D, Sakaguchi S, Miyamoto Y, Taguchi K, Muraya N, Narita Y, Sato K, Chuang VT, Maruyama T, Otagiri M, Hirata S
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Journal Title
Biological and Pharmaceutical Bulletin
Volume: 38
Issue: 3
Pages: 487-492
DOI
NAID
ISSN
0918-6158, 1347-5215
Related Report
Peer Reviewed / Open Access
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[Journal Article] Possible false-negative results on therapeutic drug monitoring of phenytoin using a particle enhanced turbidimetric inhibition immunoassay in a patient with a high level of IgM.2014
Author(s)
Hirata K, Saruwatari J, Enoki Y, Iwata K, Urata Y, Aizawa K, Ueda K, Shirouzono T, Imamura M, Moriuchi H, Ishima Y, Kadowaki D, Watanabe H, Hirata S, Maruyama T, Fukunaga E.
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Journal Title
Ther Drug Monit
Volume: 36
Issue: 5
Pages: 553-555
DOI
Related Report
Peer Reviewed
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[Journal Article] Phosphoenolpyruvate, a glycolytic intermediate, as a cytoprotectant and antioxidant in ex-vivo cold-preserved mouse liver: A potential application for organ preservation.2013
Author(s)
Kondo Y, Ishitsuka Y, Kadowaki D, Fukumoto Y, Miyamoto Y, Irikura M, Hirata S, Sato K, Maruyama T, Hamasaki N, Irie T
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Journal Title
J Pharm Pharmacol
Volume: 65
Pages: 390-401
Related Report
Peer Reviewed
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[Journal Article] (社)日本透析医学会「血液透析患者における心血管合併症の評価と治療に関するガイドライン」.2012
Author(s)
平方秀樹, 新田孝作, 友 雅司, 秋葉 隆, 伊苅裕二, 井関邦敏, 稲葉雅章, 井上 亨, 熊田佳孝, 小林修三, 常喜信彦, 庄司哲雄, 椿原美治, 鶴屋和彦, 田部井薫, 西村眞人, 長谷弘記, 平田純生, 他
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Journal Title
透析会誌
Volume: 44
Pages: 337-425
Related Report
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[Journal Article] Phosphoenolpyruvic Acid, an Intermediary Metabolite of Glycolysis, as a Potential Cytoprotectant and Anti-oxidant in HeLa Cells.2012
Author(s)
Kondo Y, Ishitsuka Y, Kadowaki D, Kuroda M, Tanaka Y, Nagatome M, Irikura M, Hirata S, Sato K, Maruyama T, Hamasaki N, Irie T
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Journal Title
Biol Pharm Bull
Volume: 35
Pages: 606-611
NAID
Related Report
Peer Reviewed
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[Journal Article] Japanese Society for Dialysis Therapy guidelines for management of cardiovascular diseases in patients on chronic hemodialysis.2012
Author(s)
Hirakata H, Nitta K, Inaba M, Shoji T, Fujii H, Kobayashi S, Tabei K, Joki N, Hase H, Nishimura M, Ozaki S, Ikari Y, Kumada Y, Tsuruya K, Fujimoto S, Inoue T, Yokoi H, Hirata S, et al
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Journal Title
Ther Apher Dial
Volume: 16
Pages: 387-435
Related Report
Peer Reviewed
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[Journal Article] Effect of acetaminophen on progression of renal damage in adenine induced renal failure model rat.2012
Author(s)
Kadowaki D, Sumikawa S, Arimizu K, Taguchi K, Kitamura K, Ishitsuka Y, Narita Y, Irie T, Maruyama T, Otagiri M, Hirata S
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Journal Title
Life Sci.
Volume: 91
Issue: 25-26
Pages: 1304-1308
DOI
Related Report
Peer Reviewed
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[Journal Article] Phosphoenolpyruvic Acid, an Intermediary Metabolite of Glycolysis, as a Potential Cytoprotectant and Anti-oxidant in HeLa Cells2012
Author(s)
Kondo Y, Ishitsuka Y, Kadowaki D, Kuroda M, Tanaka Y, Nagatome M, Irikura M, Hirata S, Sato K, Maruyama, T, Hamasaki N, Irie T
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Journal Title
Biol Pharm Bull
Volume: 35(不明)
Pages: 606-611
NAID
Related Report
Peer Reviewed
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[Journal Article] (社)日本透析医学会「血液透析患者における心血管合併症の評価と治療に関するガイドライン」2011
Author(s)
平方秀樹, 新田孝作, 友雅司, 秋葉隆, 伊苅裕二, 井関邦敏, 稲葉雅章, 井上亨, 熊田佳孝, 小林修三, 常喜信彦, 庄司哲雄, 椿原美治, 鶴屋和彦, 田部井薫, 西村眞人, 長谷弘記, 平田純生, 藤井秀毅, 藤元昭一, 横井宏佳, 島本和明, 久木山清貴
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Journal Title
透析会誌
Volume: 44(不明)
Pages: 337-425
Related Report
Peer Reviewed
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[Presentation] 血液浄化法による薬物除去2014
Author(s)
平田純生
Organizer
第9回九州臨床工学会及び第22回福岡県臨床工学会
Place of Presentation
北九州国際会議場
Year and Date
2014-10-05
Related Report
Invited
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