| Project/Area Number |
22590139
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Nagoya City University |
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Principal Investigator |
FUJII Satoshi 名古屋市立大学, 大学院・薬学研究科, 教授 (90291228)
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| Co-Investigator(Kenkyū-buntansha) |
OZEKI Tetsuya 名古屋市立大学, 大学院・薬学研究科, 教授 (60277259)
DOHI Yasuaki 名古屋市立大学, 大学院・薬学研究科, 准教授 (40305529)
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| Co-Investigator(Renkei-kenkyūsha) |
IWAKI Soichiro 名古屋市立大学, 大学院・薬学研究科, 講師 (60399962)
SUGIURA Tomonori 名古屋市立大学, 大学院・薬学研究科, 助教 (60535235)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 生理活性 / 脂質 / 薬学 / 臨床 / 内皮前駆細胞 / 動脈硬化症 / ナノ粒子 / HDL |
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| Research Abstract |
A novel strategy for conquering atherosclerosis is desirable. Athero-protective HDL is rich in bioactive lipid, sphingosine-1-phosphate (S1P). The effect of S1P on vascular endothelial cells was clarified. The relationship between plasma S1P and vascular endothelial function was evaluated. A newly synthesized biomimetic HDL nanoparticle rich in both S1P and apoA1 exhibited promising anti-inflammatory effects on endothelial cells in culture and on mice challenged with LPS.
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