| Project/Area Number |
22590141
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Hokkaido Pharmaceutical University School of Pharmacy |
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Principal Investigator |
TODA Takaki 北海道薬科大学, 薬学部, 教授 (00254706)
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| Co-Investigator(Kenkyū-buntansha) |
INOTSUME Nobuo 北海道薬科大学, 薬学部, 教授 (10191892)
HAYAKAWA Toru 北海道薬科大学, 薬学部, 教授 (50337044)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 薬物動態 / 代謝学 / 薬学 / 酵素 / ゲノム / 代謝 / 薬剤学 / 薬堂 / 薬剤堂 |
|---|
| Research Abstract |
It was shown that losartan, a drug of the treatment for hypertension, decrease the production of epoxyeicosatrienoic acids (EETs) from arachidonic acid by inhibiting some cytochrome P450 (CYP)s. This inhibitory effect was also found in telmisartan, which is the similar anti-hypertensive as losartan. EETs have cardioprotective effects. Therefore, it was suggested that the decrease of EETs production would be related tothe cardiovascular side effects such as arrhythmia of these drugs.
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