| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
The purpose of this study was to clarify whether 5-fluorouracil (5-FU)-induced myelotoxicity is a cause of oxidative stress and to demonstrate machineryinvolved in tissue-specific development of adverse-drug reactions. 5-FU-inducedmyelotoxicity in mice was directly linked to intracellular glutathione and activity of Nrf2,indicating that oxidative stress is involved in the process. In addition, 5-FU induced different responses of p53 in the bone marrow and tumor xenografts, which could be participated in the tissue selectivity of the 5-FU-mediated toxicity.
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