| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
The objective of this study was to develop a modeling and simulation strategy for evaluation of drug absorption profile and for prediction of drug concentration-time curves in human after oral administration. We focused on Tmax and Cmax as easily available pharmacokinetic parameters in animals and human during drug development process, and prediction strategy was constructed by the method of convolution with a use of numerical Laplace transform algorithm. Based on the pharmacokinetic parameters for many drugs in animals and human obtained from literatures, we examined the validity of the prediction strategy and evaluated the predictability. It was suggested that the predictability of the time course profile is dependent on the predictability of Cmax.
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