The absorption and disposition of zinc : The relation with absorptive transporter, ZIP and secretory transporter, ZnT
| Project/Area Number |
22590154
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Kyoto Pharmaceutical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Akira 京都薬科大学, 薬学部, 教授 (00166779)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 薬物動態 / 代謝学 / メタロミクス / 亜鉛 / 金属元素 / 必須微量元素 / トランスポーター / 吸収 / メタロミスク / メトロミクス / 体内動態 |
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| Research Abstract |
Concentrations of zinc in the tissue of the rat are significantly correlated with the expression levels of metallothionein-1 in the tissue, suggesting that zinc is bound with metallothioneins in the tissue. As the results of studies using the rat or the cultured cell, it is suggested that zinc is absorbed in part by a carrier-mediated transport. The significant relation was not observed between the activity of a specific transporter and the intestinal transport of zinc, indicating that some transporters are cooperatively involved in the intestinal absorption of zinc.
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Report
(4 results)
Research Products
(14 results)
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[Journal Article] In vitro study on the transport of zinc across intestinal epithelial cells using Caco-2 monolayers and isolated rat intestinal membranes2012
Author(s)
Tohru Yasuno, Hiroki Okamoto, Miho Nagai, Shunsuke Kimura, Takanori Yamamoto, Kozue Nagano, Tomoyuki Furubayashi, Yutaka Yoshikawa, Hiroyuki Yasui, Hidemasa Katsumi, Toshiyasu Sakane, Akira Yamamoto
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Journal Title
Biologicaland Pharmaceutical Bulletin
Volume: Vol. 35, No.4
Pages: 588-593
NAID
Related Report
Peer Reviewed
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[Journal Article] The disposition and intestinal absorption of zinc in rats2011
Author(s)
Tohru Yasuno, Hiroki Okamoto, Miho Nagai, Shunsuke Kimura, Takanori Yamamoto, Kozue Nagano, Tomoyuki Furubayashi, YutakaYoshikawa, Hiroyuki Yasui, Hidemasa Katsumi, Toshiyasu Sakane, Akira Yamamoto.
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Journal Title
European Journal of PharmaceuticalSciences
Volume: Vol.44, No.3
Pages: 410-415
Related Report
Peer Reviewed
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