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The absorption and disposition of zinc : The relation with absorptive transporter, ZIP and secretory transporter, ZnT

Research Project

Project/Area Number 22590154
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Medical pharmacy
Research InstitutionKyoto Pharmaceutical University

Principal Investigator

SAKANE Toshiyasu  京都薬科大学, 薬学部, 准教授 (50215638)

Co-Investigator(Kenkyū-buntansha) YAMAMOTO Akira  京都薬科大学, 薬学部, 教授 (00166779)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords薬物動態 / 代謝学 / メタロミクス / 亜鉛 / 金属元素 / 必須微量元素 / トランスポーター / 吸収 / メタロミスク / メトロミクス / 体内動態
Research Abstract

Concentrations of zinc in the tissue of the rat are significantly correlated with the expression levels of metallothionein-1 in the tissue, suggesting that zinc is bound with metallothioneins in the tissue. As the results of studies using the rat or the cultured cell, it is suggested that zinc is absorbed in part by a carrier-mediated transport. The significant relation was not observed between the activity of a specific transporter and the intestinal transport of zinc, indicating that some transporters are cooperatively involved in the intestinal absorption of zinc.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (14 results)

All 2012 2011 2010 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (10 results)

  • [Journal Article] In vitro study on the transport of zinc across intestinal epithelial cells using Caco-2 monolayers and isolated rat intestinal membranes2012

    • Author(s)
      Tohru Yasuno, Hiroki Okamoto, Miho Nagai, Shunsuke Kimura, Takanori Yamamoto, Kozue Nagano, Tomoyuki Furubayashi, Yutaka Yoshikawa, Hiroyuki Yasui, Hidemasa Katsumi, Toshiyasu Sakane, Akira Yamamoto
    • Journal Title

      Biologicaland Pharmaceutical Bulletin

      Volume: Vol. 35, No.4 Pages: 588-593

    • NAID

      130001872209

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] In vitro study on the transport of zinc across intestinal epithelial cells using Caco-2 monolayers and isolated ratintestinal membranes2012

    • Author(s)
      Tohru Yasuno
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 35 Pages: 889-894

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The disposition and intestinal absorption of zinc in rats2011

    • Author(s)
      Tohru Yasuno, Hiroki Okamoto, Miho Nagai, Shunsuke Kimura, Takanori Yamamoto, Kozue Nagano, Tomoyuki Furubayashi, YutakaYoshikawa, Hiroyuki Yasui, Hidemasa Katsumi, Toshiyasu Sakane, Akira Yamamoto.
    • Journal Title

      European Journal of PharmaceuticalSciences

      Volume: Vol.44, No.3 Pages: 410-415

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The disposition and intestinal absorption of zinc in rats2011

    • Author(s)
      Tohru Yasuno
    • Journal Title

      European Journal of Pharmaceutical Sciences

      Volume: 43 Pages: 410-415

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] TNBS誘発大腸炎モデルに対する亜鉛の治療効果2012

    • Author(s)
      妹尾彩香
    • Organizer
      日本薬剤学会第27年会
    • Place of Presentation
      神戸国際会議場(神戸市)
    • Year and Date
      2012-05-26
    • Related Report
      2012 Final Research Report
  • [Presentation] 亜鉛及び亜鉛関連化合物の消化管吸収性の評価2011

    • Author(s)
      永井美帆
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      ツインメッセ静岡(静岡市)
    • Year and Date
      2011-03-29
    • Related Report
      2012 Final Research Report
  • [Presentation] 亜鉛及び亜鉛関連化合物の消化管吸収性の評価2011

    • Author(s)
      永井美帆
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      ツインメッセ静岡(静岡県)
    • Year and Date
      2011-03-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] 亜鉛の体内動態とTransporter(ZIP)との機能的関連2010

    • Author(s)
      山本貴紀
    • Organizer
      第2回メタロミクス研究会
    • Place of Presentation
      京都薬科大学(京都市)
    • Year and Date
      2010-11-03
    • Related Report
      2012 Final Research Report
  • [Presentation] 亜鉛の体内動態とTransporter (ZIP)との機能的関連2010

    • Author(s)
      山本貴紀
    • Organizer
      第2回メタロミクス研究会
    • Place of Presentation
      京都薬科大学(京都府)
    • Year and Date
      2010-11-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] ラットにおける亜鉛の吸収及び分布とトランスポーター(ZIPs)との関係2010

    • Author(s)
      山本貴紀
    • Organizer
      日本薬物動態学会第25年会
    • Place of Presentation
      大宮ソニックホール(さいたま市)
    • Year and Date
      2010-10-08
    • Related Report
      2012 Final Research Report
  • [Presentation] ラットにおける亜鉛の吸収及び分布とトランスポーター(ZIPs)との関係2010

    • Author(s)
      山本貴紀
    • Organizer
      日本薬物動態学会第25年会
    • Place of Presentation
      大宮ソニックホール(埼玉県)
    • Year and Date
      2010-10-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] 亜鉛の体内動態とTransporter(ZIP)との機能的関連II2010

    • Author(s)
      山本貴紀
    • Organizer
      日本薬剤学会第25年会
    • Place of Presentation
      徳島県郷土文化会館(徳島市)
    • Year and Date
      2010-05-14
    • Related Report
      2012 Final Research Report
  • [Presentation] 亜鉛の体内動態とTransporter (ZIP)との機能的関連II2010

    • Author(s)
      山本貴紀
    • Organizer
      日本薬剤学会第25年会
    • Place of Presentation
      徳島県郷土文化会館(徳島県)
    • Year and Date
      2010-05-14
    • Related Report
      2010 Annual Research Report
  • [Presentation] TNBS誘発大腸炎モデルに対する亜鉛の治療効果

    • Author(s)
      妹尾彩香
    • Organizer
      日本薬剤学会第27年会
    • Place of Presentation
      神戸国際会議場
    • Related Report
      2012 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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