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Significance of feeding regulation of peptides in eating abnormality in digestive diseases

Research Project

Project/Area Number 22590156
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Medical pharmacy
Research InstitutionKobe Pharmaceutical University

Principal Investigator

MIZUNO Shigeto  神戸薬科大学, 薬学部, 教授 (80368349)

Co-Investigator(Kenkyū-buntansha) INUI Akio  鹿児島大学, 大学院・医歯学総合研究科, 教授 (80168418)
ASAKAWA Akihiro  鹿児島大学, 大学院・医歯学総合研究科, 准教授 (10452947)
KAKIHARA Hiroaki  京都大学, 大学院・薬学研究科, 教授 (20351314)
Research Collaborator ANDO Takashi  社会保険京都病院, 消化器内科
MITSUMOTO Yasuhide  社会保険京都病院, 消化器内科
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords消化器疾患 / 摂食調節ペプチド / ヘリコバクター・ピロリ / 臨床疫学研究 / インターフェロン / 摂量調節ペプチド
Research Abstract

Helicobacter pylori is a bacterium that has infected more than half of the Japanese population and is associated with chronic gastritis, peptic ulcer, and gastric cancer. We conducted a clinical study on the association between Helicobacter pylori infection and various feeding and metabolic regulating factors. The result raises the possibility that Helicobacter pylori infection affects the host’s nutritional status through changes in the plasma levels of ghrelin, which regulates feeding behavior, and adiponectin, which regulates metabolic status.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (23 results)

All 2013 2012 2011 2010 Other

All Journal Article (18 results) (of which Peer Reviewed: 18 results) Presentation (4 results) Remarks (1 results)

  • [Journal Article] Linoleoylethanolamide reduces lipopolysaccharide-induced inflammation in macrophages and ameliorates2,4-dinitrofluorobenzene-induced contact dermatitis in mice.2013

    • Author(s)
      Ishida T, Nishiumi S, Tanahashi T, Yamasaki A, Yamazaki A, Akashi T, Miki I, Kondo Y, Inoue J, Kawauchi S, Azuma T, Yoshida M, Mizuno S.
    • Journal Title

      Eur JPharmacol

      Volume: 699(1-3) Pages: 6-13

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impact of Helicobacter pylori Eradication on Circulating Adiponectin in Humans.2013

    • Author(s)
      Ando T, Ishikawa T, Takagi T, Imamoto E, Kishimoto E, Okajima A, Uchiyama K, Handa O, Yagi N, Kokura S, NaitoY, Mizuno S, Asakawa A, Inui A, Yoshikawa T.
    • Journal Title

      Helicobacter

      Volume: 18(2) Pages: 158-64

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impact of Helicobacter pylori Eradication on Circulating Adiponectin in Humans.2013

    • Author(s)
      Takashi Ando
    • Journal Title

      Helicobacter

      Volume: 18 Issue: 2 Pages: 158-164

    • DOI

      10.1111/hel.12028

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] THRB genetic polymorphisms can predict severe myelotoxicity after definitive chemoradiotherapy in patients with esophageal squamous cell carcinoma.2012

    • Author(s)
      Miki I, Nakamura T, Kuwahara A,Yamamori M, Nishiguchi K, Tamura T, Okuno T, Omatsu H, Mizuno S, Hirai M, Azuma T, Sakaeda T.
    • Journal Title

      Int J Med Sci.

      Volume: 9(9) Pages: 748-56

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Plasma ghrelin isoforms and gastric ghrelin O-acyltransferase expression are influenced by Helicobacter pyloristatus.2012

    • Author(s)
      Ando T, Mizuno S, Ishida T, Kondo Y, Miki I, Yoshida M, Azuma T, Ishikawa T, Takagi T, Yagi N, Kokura S, Naito Y, Yoshikawa T, Asakawa A, Inui A.
    • Journal Title

      Nutrition.

      Volume: 28(10) Pages: 967-72

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Soluble β-glucan fromGrifola frondosa induces proliferation and Dectin-1/Syk signaling in resident macrophages via the GM-CSF autocrine pathway.2012

    • Author(s)
      Masuda Y, Togo T, Mizuno S, Konishi M,Nanba H.
    • Journal Title

      J LeukocBiol.

      Volume: 91(4) Pages: 547-56

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] AP1B plays an important role in intestinal tumorigenesis with the truncating mutation of an APC gene.2012

    • Author(s)
      Mimura M, Masuda A, Nishiumi S,Kawakami K, Fujishima Y, YoshieT, Mizuno S, Miki I, Ohno H, Hase K, Minamoto T, Azuma T, Yoshida M.
    • Journal Title

      Int J Cancer.

      Volume: 130(5) Pages: 1011-20

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Plasma ghrelin isoforms and gastric ghrelin O-acyltransferase expression are influenced by Helicobacter pylori status2012

    • Author(s)
      Ando T
    • Journal Title

      Nutrition

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibitory effects of glycyrrhetinic acid on DNA polymerase and inflammatory activities.2011

    • Author(s)
      Ishida T, Mizushina Y, Yagi S, IrinoY, Nishiumi S, Miki I, Kondo Y, Mizuno S, Yoshida H, Azuma T, Yoshida M.
    • Journal Title

      Evid Based Complement Alternat Med.Epub

      Volume: 2012 Pages: 1-9

    • DOI

      10.1155/2012/650514

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Helicobacter suis KB1 derived from pig gastric lymphoid follicles induces the formation of gastric lymphoid follicles in mice through the activation of B cells and CD4 positive cells.2011

    • Author(s)
      Yamamoto K, Tanaka H, Nishitani Y,Nishiumi S, Miki I, Takenaka M, Nobutani K, Mimura T, Ben Suleiman Y, Mizuno S, Kawai M, Uchiyama I,Yoshida M, Azuma T.
    • Journal Title

      Microbes Infect

      Volume: 13(7) Pages: 697-708

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Vitamin K3Attenuates Cerulein-Induced Acute Pancreatitis Through Inhibition of the Autophagic Pathway.2011

    • Author(s)
      Chinzei R, Masuda A, Nishiumi S,Nishida M, Onoyama M, Sanuki T, Fujita T, Moritoh S, Itoh T, Kutsumi H, Mizuno S, Azuma T, Yoshida M.
    • Journal Title

      Pancreas

      Volume: 40(1) Pages: 84-94

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prescreening of a High-Risk Group for Gastric Cancer by Serologically Determined Helicobacter pylori Infection and Atrophic Gastritis.2010

    • Author(s)
      Mizuno S, Miki I, Ishida T, Yoshida M,Onoyama M, Azuma T, Habu Y, Inokuchi H, Ozasa K, Miki K, Watanabe Y.
    • Journal Title

      DigDis Sci

      Volume: 55(11) Pages: 3132-7

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Resolvin E1, anendogenous lipid mediator derived from eicosapentaenoic acid, prevents dextran sulfate sodium-induced colitis.2010

    • Author(s)
      Ishida T, Yoshida M, Arita M,Nishitani Y, Nishiumi S, MasudaA, Mizuno S, Takagawa T, Morita Y, Kutsumi H, Inokuchi H, Serhan CN, Blumberg RS, Azuma T.
    • Journal Title

      Inflamm Bowel Dis

      Volume: 16(1) Pages: 87-95

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Potential antitumor activity of a low-molecular-weight protein fraction from Grifola frondosa through enhancement of cytokineproduction.2010

    • Author(s)
      Kodama N, Mizuno S, Nanba H, Saito N.
    • Journal Title

      J Med Food

      Volume: 13(1) Pages: 20-30

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Monoacetylcurcumin strongly regulates inflammatory responses through inhibition of NF-kappaB activation.2010

    • Author(s)
      Nishida M, Nishiumi S, Mizushina Y,Fujishima Y, Yamamoto K, Masuda A, Mizuno S, Fujita T, Morita Y, Kutsumi H, Yoshida H, Azuma T, Yoshida M.
    • Journal Title

      Int J Mol Med

      Volume: 25(5) Pages: 761-7

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Vitamin K(3) attenuateslipopolysaccharide-induced acute lung injury through inhibition of nuclear factor-kappaB activation.2010

    • Author(s)
      Tanaka S, Nishiumi S, Nishida M,Mizushina Y, Kobayashi K, Masuda A, Fujita T, Morita Y, Mizuno S, Kutsumi H, Azuma T, Yoshida M.
    • Journal Title

      Clin Exp Immunol

      Volume: 160(2) Pages: 283-92

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of a hot water-soluble extraction from Grifola frondosa on the viability of a human monocyte cell line exposed to mitomycin C.2010

    • Author(s)
      Kodama N, Mizuno S, Asakawa A, Inui A, Nanba H.
    • Journal Title

      Mycoscience

      Volume: 51 Pages: 134-8

    • NAID

      10027043356

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Serum metabolomics as a novel diagnostic approach for pancreatic cancer.2010

    • Author(s)
      Nishiumi S, Shinohara M, Ikeda A, Yoshie T, Hatano N, Kakuyama S, Mizuno S, Sanuki T, Kutsumi H, Fukusaki E, Azuma T, Takenawa T, Yoshida M.
    • Journal Title

      Metabolomics

      Volume: 6(4) Pages: 518-528

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Presentation] HELICOBACTER PYLORI ERADICATION INCREASES THE CIRCULATING ADIPONECTIN LEVELS IN HUMANS.2012

    • Author(s)
      Ando T, Ishikawa T, Mitsumoto Y,Imamoto E, Kishimoto E, Okajima A, Suzuki T, Mizushima K, Uchiyama K, Handa O, Takagi T, Yagi N, Kokura S, Naito Y, Mizuno S, Asakawa A, Inui A.
    • Organizer
      The United European Gastroenterology Week (UEGW) 2012.
    • Place of Presentation
      Amsterdam, Holland
    • Year and Date
      2012-10-22
    • Related Report
      2012 Final Research Report
  • [Presentation] 胃内グレリン・GOAT発現および循環グレリン値に対するH.pylori感染の影響2012

    • Author(s)
      安藤貴志,水野成人,乾明夫
    • Organizer
      第98回日本消化器病学会総会
    • Place of Presentation
      東京
    • Year and Date
      2012-04-19
    • Related Report
      2012 Final Research Report
  • [Presentation] EFFECT OF GOAT OF THE STOMACH ON THE ACYLATION OF SERUM GHRELIN ACCORDING TO H. PYLORI STATUS IN HUMANS.2011

    • Author(s)
      Ando T, Ishida T, Mitsumoto Y, Imamoto E, Kishimoto E, Kato N, Okajima A, Suzuki T, Uchiyama K, Ishikawa T, Takagi T, Handa O, Yagi N, Kokura S, Naito Y, Yoshikawa T, TakeuchiM, Mizuno S, Asakawa A, Inui A.
    • Organizer
      The United European Gastroenterology Week (UEGW)2011.
    • Place of Presentation
      Stockholm, Sweden
    • Year and Date
      2011-10-24
    • Related Report
      2012 Final Research Report
  • [Presentation] EFFECT OF GOAT OF THE STOMACH ON THE ACYLATION OF SERUM GHRELIN ACCORDING TO H.PYLORI STATUS IN HUMANS2011

    • Author(s)
      Ando T
    • Organizer
      The United European Gastroenterology Week (UEGW) 2011
    • Place of Presentation
      ストックホルム
    • Year and Date
      2011-10-24
    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.kobepharma-u.ac.jp/

    • Related Report
      2012 Final Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

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