Significance of feeding regulation of peptides in eating abnormality in digestive diseases

• Project/Area Number: 22590156
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Medical pharmacy
• Research Institution: Kobe Pharmaceutical University
• Principal Investigator: MIZUNO Shigeto 神戸薬科大学, 薬学部, 教授 (80368349)
• Co-Investigator(Kenkyū-buntansha): INUI Akio 鹿児島大学, 大学院・医歯学総合研究科, 教授 (80168418) ; ASAKAWA Akihiro 鹿児島大学, 大学院・医歯学総合研究科, 准教授 (10452947) ; KAKIHARA Hiroaki 京都大学, 大学院・薬学研究科, 教授 (20351314)
• Research Collaborator: ANDO Takashi 社会保険京都病院, 消化器内科 ; MITSUMOTO Yasuhide 社会保険京都病院, 消化器内科
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 消化器疾患 / 摂食調節ペプチド / ヘリコバクター・ピロリ / 臨床疫学研究 / インターフェロン / 摂量調節ペプチド

Research Abstract

Helicobacter pylori is a bacterium that has infected more than half of the Japanese population and is associated with chronic gastritis, peptic ulcer, and gastric cancer. We conducted a clinical study on the association between Helicobacter pylori infection and various feeding and metabolic regulating factors. The result raises the possibility that Helicobacter pylori infection affects the host’s nutritional status through changes in the plasma levels of ghrelin, which regulates feeding behavior, and adiponectin, which regulates metabolic status.

Research Products

• [Journal Article] Linoleoylethanolamide reduces lipopolysaccharide-induced inflammation in macrophages and ameliorates2,4-dinitrofluorobenzene-induced contact dermatitis in mice. (2013)
  • Author(s): Ishida T, Nishiumi S, Tanahashi T, Yamasaki A, Yamazaki A, Akashi T, Miki I, Kondo Y, Inoue J, Kawauchi S, Azuma T, Yoshida M, Mizuno S.
  • Journal Title: Eur JPharmacol Volume: 699(1-3) Pages: 6-13
  • Peer Reviewed
• [Journal Article] Impact of Helicobacter pylori Eradication on Circulating Adiponectin in Humans. (2013)
  • Author(s): Ando T, Ishikawa T, Takagi T, Imamoto E, Kishimoto E, Okajima A, Uchiyama K, Handa O, Yagi N, Kokura S, NaitoY, Mizuno S, Asakawa A, Inui A, Yoshikawa T.
  • Journal Title: Helicobacter Volume: 18(2) Pages: 158-64
  • Peer Reviewed
• [Journal Article] Impact of Helicobacter pylori Eradication on Circulating Adiponectin in Humans. (2013)
  • Author(s): Takashi Ando
  • Journal Title: Helicobacter Volume: 18 Issue: 2 Pages: 158-164
  • DOI: 10.1111/hel.12028
  • Peer Reviewed
• [Journal Article] THRB genetic polymorphisms can predict severe myelotoxicity after definitive chemoradiotherapy in patients with esophageal squamous cell carcinoma. (2012)
  • Author(s): Miki I, Nakamura T, Kuwahara A,Yamamori M, Nishiguchi K, Tamura T, Okuno T, Omatsu H, Mizuno S, Hirai M, Azuma T, Sakaeda T.
  • Journal Title: Int J Med Sci. Volume: 9(9) Pages: 748-56
  • Peer Reviewed
• [Journal Article] Plasma ghrelin isoforms and gastric ghrelin O-acyltransferase expression are influenced by Helicobacter pyloristatus. (2012)
  • Author(s): Ando T, Mizuno S, Ishida T, Kondo Y, Miki I, Yoshida M, Azuma T, Ishikawa T, Takagi T, Yagi N, Kokura S, Naito Y, Yoshikawa T, Asakawa A, Inui A.
  • Journal Title: Nutrition. Volume: 28(10) Pages: 967-72
  • Peer Reviewed
• [Journal Article] Soluble β-glucan fromGrifola frondosa induces proliferation and Dectin-1/Syk signaling in resident macrophages via the GM-CSF autocrine pathway. (2012)
  • Author(s): Masuda Y, Togo T, Mizuno S, Konishi M,Nanba H.
  • Journal Title: J LeukocBiol. Volume: 91(4) Pages: 547-56
  • Peer Reviewed
• [Journal Article] AP1B plays an important role in intestinal tumorigenesis with the truncating mutation of an APC gene. (2012)
  • Author(s): Mimura M, Masuda A, Nishiumi S,Kawakami K, Fujishima Y, YoshieT, Mizuno S, Miki I, Ohno H, Hase K, Minamoto T, Azuma T, Yoshida M.
  • Journal Title: Int J Cancer. Volume: 130(5) Pages: 1011-20
  • Peer Reviewed
• [Journal Article] Plasma ghrelin isoforms and gastric ghrelin O-acyltransferase expression are influenced by Helicobacter pylori status (2012)
  • Author(s): Ando T
  • Journal Title: Nutrition
  • Peer Reviewed
• [Journal Article] Inhibitory effects of glycyrrhetinic acid on DNA polymerase and inflammatory activities. (2011)
  • Author(s): Ishida T, Mizushina Y, Yagi S, IrinoY, Nishiumi S, Miki I, Kondo Y, Mizuno S, Yoshida H, Azuma T, Yoshida M.
  • Journal Title: Evid Based Complement Alternat Med.Epub Volume: 2012 Pages: 1-9
  • DOI: 10.1155/2012/650514
  • Peer Reviewed
• [Journal Article] Helicobacter suis KB1 derived from pig gastric lymphoid follicles induces the formation of gastric lymphoid follicles in mice through the activation of B cells and CD4 positive cells. (2011)
  • Author(s): Yamamoto K, Tanaka H, Nishitani Y,Nishiumi S, Miki I, Takenaka M, Nobutani K, Mimura T, Ben Suleiman Y, Mizuno S, Kawai M, Uchiyama I,Yoshida M, Azuma T.
  • Journal Title: Microbes Infect Volume: 13(7) Pages: 697-708
  • Peer Reviewed
• [Journal Article] Vitamin K3Attenuates Cerulein-Induced Acute Pancreatitis Through Inhibition of the Autophagic Pathway. (2011)
  • Author(s): Chinzei R, Masuda A, Nishiumi S,Nishida M, Onoyama M, Sanuki T, Fujita T, Moritoh S, Itoh T, Kutsumi H, Mizuno S, Azuma T, Yoshida M.
  • Journal Title: Pancreas Volume: 40(1) Pages: 84-94
  • Peer Reviewed
• [Journal Article] Prescreening of a High-Risk Group for Gastric Cancer by Serologically Determined Helicobacter pylori Infection and Atrophic Gastritis. (2010)
  • Author(s): Mizuno S, Miki I, Ishida T, Yoshida M,Onoyama M, Azuma T, Habu Y, Inokuchi H, Ozasa K, Miki K, Watanabe Y.
  • Journal Title: DigDis Sci Volume: 55(11) Pages: 3132-7
  • Peer Reviewed
• [Journal Article] Resolvin E1, anendogenous lipid mediator derived from eicosapentaenoic acid, prevents dextran sulfate sodium-induced colitis. (2010)
  • Author(s): Ishida T, Yoshida M, Arita M,Nishitani Y, Nishiumi S, MasudaA, Mizuno S, Takagawa T, Morita Y, Kutsumi H, Inokuchi H, Serhan CN, Blumberg RS, Azuma T.
  • Journal Title: Inflamm Bowel Dis Volume: 16(1) Pages: 87-95
  • Peer Reviewed
• [Journal Article] Potential antitumor activity of a low-molecular-weight protein fraction from Grifola frondosa through enhancement of cytokineproduction. (2010)
  • Author(s): Kodama N, Mizuno S, Nanba H, Saito N.
  • Journal Title: J Med Food Volume: 13(1) Pages: 20-30
  • Peer Reviewed
• [Journal Article] Monoacetylcurcumin strongly regulates inflammatory responses through inhibition of NF-kappaB activation. (2010)
  • Author(s): Nishida M, Nishiumi S, Mizushina Y,Fujishima Y, Yamamoto K, Masuda A, Mizuno S, Fujita T, Morita Y, Kutsumi H, Yoshida H, Azuma T, Yoshida M.
  • Journal Title: Int J Mol Med Volume: 25(5) Pages: 761-7
  • Peer Reviewed
• [Journal Article] Vitamin K(3) attenuateslipopolysaccharide-induced acute lung injury through inhibition of nuclear factor-kappaB activation. (2010)
  • Author(s): Tanaka S, Nishiumi S, Nishida M,Mizushina Y, Kobayashi K, Masuda A, Fujita T, Morita Y, Mizuno S, Kutsumi H, Azuma T, Yoshida M.
  • Journal Title: Clin Exp Immunol Volume: 160(2) Pages: 283-92
  • Peer Reviewed
• [Journal Article] Effect of a hot water-soluble extraction from Grifola frondosa on the viability of a human monocyte cell line exposed to mitomycin C. (2010)
  • Author(s): Kodama N, Mizuno S, Asakawa A, Inui A, Nanba H.
  • Journal Title: Mycoscience Volume: 51 Pages: 134-8
  • NAID: 10027043356
  • Peer Reviewed
• [Journal Article] Serum metabolomics as a novel diagnostic approach for pancreatic cancer. (2010)
  • Author(s): Nishiumi S, Shinohara M, Ikeda A, Yoshie T, Hatano N, Kakuyama S, Mizuno S, Sanuki T, Kutsumi H, Fukusaki E, Azuma T, Takenawa T, Yoshida M.
  • Journal Title: Metabolomics Volume: 6(4) Pages: 518-528
  • Peer Reviewed
• [Presentation] HELICOBACTER PYLORI ERADICATION INCREASES THE CIRCULATING ADIPONECTIN LEVELS IN HUMANS. (2012)
  • Author(s): Ando T, Ishikawa T, Mitsumoto Y,Imamoto E, Kishimoto E, Okajima A, Suzuki T, Mizushima K, Uchiyama K, Handa O, Takagi T, Yagi N, Kokura S, Naito Y, Mizuno S, Asakawa A, Inui A.
  • Organizer: The United European Gastroenterology Week (UEGW) 2012.
  • Place of Presentation: Amsterdam, Holland
  • Year and Date: 2012-10-22
• [Presentation] 胃内グレリン・GOAT発現および循環グレリン値に対するH.pylori感染の影響 (2012)
  • Author(s): 安藤貴志,水野成人,乾明夫
  • Organizer: 第98回日本消化器病学会総会
  • Place of Presentation: 東京
  • Year and Date: 2012-04-19
• [Presentation] EFFECT OF GOAT OF THE STOMACH ON THE ACYLATION OF SERUM GHRELIN ACCORDING TO H. PYLORI STATUS IN HUMANS. (2011)
  • Author(s): Ando T, Ishida T, Mitsumoto Y, Imamoto E, Kishimoto E, Kato N, Okajima A, Suzuki T, Uchiyama K, Ishikawa T, Takagi T, Handa O, Yagi N, Kokura S, Naito Y, Yoshikawa T, TakeuchiM, Mizuno S, Asakawa A, Inui A.
  • Organizer: The United European Gastroenterology Week (UEGW)2011.
  • Place of Presentation: Stockholm, Sweden
  • Year and Date: 2011-10-24
• [Presentation] EFFECT OF GOAT OF THE STOMACH ON THE ACYLATION OF SERUM GHRELIN ACCORDING TO H.PYLORI STATUS IN HUMANS (2011)
  • Author(s): Ando T
  • Organizer: The United European Gastroenterology Week (UEGW) 2011
  • Place of Presentation: ストックホルム
  • Year and Date: 2011-10-24
• [Remarks]
  • URL: http://www.kobepharma-u.ac.jp/