| Project/Area Number |
22590163
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Fukuoka University |
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Principal Investigator |
SHUTO Hideki 福岡大学, 薬学部, 准教授 (60412574)
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| Co-Investigator(Kenkyū-buntansha) |
DOHGU Shinya 福岡大学, 薬学部, 准教授 (60399186)
TAKATA Fuyuko 福岡大学, 薬学部, 助教 (70412575)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 血液脳関門 / バイオマーカー / RANTES / 中枢性副作用 / データーマイニング / オーダーメイド医療 / Blood-Brain Barrier / TNF-α / Oncostatin M / PAI-1 / Cyclosporine A / Acute Liver Failure / P-glycoprotein / Tight Junction |
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| Research Abstract |
The Blood-brain barrier (BBB) strictly controls the exchanges between the blood and the brain compartments by limiting passive diffusion of solutes and facilitating selective efflux of solutes by transporters. Accumulating experimental and clinical evidence indicate that BBB dysfunctions are associated with a number of serious CNS diseases and BBB impermeable drugs-induced neurotoxicity. However, little is known about the biomarker to predict BBB function. In this study, we present evidence that some bioactive substances (TNF-〓, RANTE, and S100A4 etc) in the serum could serve as predictive biomarkers for pathological alterations of the BBB functions.
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