| Project/Area Number |
22590172
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Kanazawa University |
|---|
Principal Investigator |
|
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| Co-Investigator(Renkei-kenkyūsha) |
KATO Yukio 金沢大学, 薬学系, 教授 (30251440)
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| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 精巣 / 造精細胞 / セルトリ細胞 / ノックアウトマウス / Yeast Two-Hybrid法 / 精子形成 / 細胞接着分子 / アダプター蛋白質 |
|---|
| Research Abstract |
Cell adhesion molecule-1(Cadm1) is expressed in only spermatogenic cells. It is involved in spermatogenesis by the interaction with poliovirus receptor expressed in Sertoli cells. Cadm1-deficient mice have male infertility due to defective spermatogenesis, in which abnormal spermatids and apoptotic cells are prominent. In the present study, we identified two adaptor molecules, Bspry and Mpp6, which interact with Cadm1. Both molecules localized in elongating spermatids of the testis
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